COVID-19: a potential driver of immune-mediated breast cancer recurrence?
Breast Cancer Res
; 22(1): 117, 2020 10 30.
Article
in English
| MEDLINE | ID: covidwho-895020
ABSTRACT
Severe coronavirus disease 2019 (COVID-19) causes a hyperactivation of immune cells, resulting in lung inflammation. Recent studies showed that COVID-19 induces the production of factors previously implicated in the reawakening of dormant breast cancer cells such as neutrophil extracellular traps (NETs). The presence of NETs and of a pro-inflammatory microenvironment may therefore promote breast cancer reactivation, increasing the risk of pulmonary metastasis. Further studies will be required to confirm the link between COVID-19 and cancer recurrence. However, an increased awareness on the potential risks for breast cancer patients with COVID-19 may lead to improved treatment strategies to prevent metastatic relapse.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Breast Neoplasms
/
Coronavirus Infections
/
Neoplasm Recurrence, Local
Type of study:
Prognostic study
Limits:
Female
/
Humans
Language:
English
Journal:
Breast Cancer Res
Journal subject:
Neoplasms
Year:
2020
Document Type:
Article
Affiliation country:
S13058-020-01360-0
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