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SARS-CoV-2/Renin-Angiotensin System: Deciphering the Clues for a Couple with Potentially Harmful Effects on Skeletal Muscle.
Gonzalez, Andrea; Orozco-Aguilar, Josué; Achiardi, Oscar; Simon, Felipe; Cabello-Verrugio, Claudio.
  • Gonzalez A; Laboratory of Muscle Pathology, Fragility and Aging, Department of Biological Sciences, Faculty of Life Sciences, Universidad Andres Bello, Santiago 8370146, Chile.
  • Orozco-Aguilar J; Millennium Institute on Immunology and Immunotherapy, Santiago 8370146, Chile.
  • Achiardi O; Center for the Development of Nanoscience and Nanotechnology (CEDENNA), Universidad de Santiago de Chile, Santiago 8350709, Chile.
  • Simon F; Laboratory of Muscle Pathology, Fragility and Aging, Department of Biological Sciences, Faculty of Life Sciences, Universidad Andres Bello, Santiago 8370146, Chile.
  • Cabello-Verrugio C; Millennium Institute on Immunology and Immunotherapy, Santiago 8370146, Chile.
Int J Mol Sci ; 21(21)2020 Oct 24.
Article in English | MEDLINE | ID: covidwho-895370
ABSTRACT
Severe acute respiratory syndrome coronavirus (SARS-CoV-2) has produced significant health emergencies worldwide, resulting in the declaration by the World Health Organization of the coronavirus disease 2019 (COVID-19) pandemic. Acute respiratory syndrome seems to be the most common manifestation of COVID-19. A high proportion of patients require intensive care unit admission and mechanical ventilation (MV) to survive. It has been well established that angiotensin-converting enzyme type 2 (ACE2) is the primary cellular receptor for SARS-CoV-2. ACE2 belongs to the renin-angiotensin system (RAS), composed of several peptides, such as angiotensin II (Ang II) and angiotensin (1-7) (Ang-(1-7)). Both peptides regulate muscle mass and function. It has been described that SARS-CoV-2 infection, by direct and indirect mechanisms, affects a broad range of organ systems. In the skeletal muscle, through unbalanced RAS activity, SARS-CoV-2 could induce severe consequences such as loss of muscle mass, strength, and physical function, which will delay and interfere with the recovery process of patients with COVID-19. This article discusses the relationship between RAS, SARS-CoV-2, skeletal muscle, and the potentially harmful consequences for skeletal muscle in patients currently infected with and recovering from COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Renin-Angiotensin System / Muscular Atrophy / Coronavirus Infections / Muscle, Skeletal Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: Ijms21217904

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Renin-Angiotensin System / Muscular Atrophy / Coronavirus Infections / Muscle, Skeletal Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: Ijms21217904