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Ibuprofen and NSAID Use in COVID-19 Infected Patients Is Not Associated with Worse Outcomes: A Prospective Cohort Study.
Abu Esba, Laila Carolina; Alqahtani, Rahaf Ali; Thomas, Abin; Shamas, Nour; Alswaidan, Lolowa; Mardawi, Gahdah.
  • Abu Esba LC; Pharmaceutical Care Department, Ministry of the National Guard, Health Affairs, Riyadh, Saudi Arabia. abuesbala@ngha.med.sa.
  • Alqahtani RA; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. abuesbala@ngha.med.sa.
  • Thomas A; College of Pharmacy, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. abuesbala@ngha.med.sa.
  • Shamas N; Pharmaceutical Care Department, Ministry of the National Guard, Health Affairs, Riyadh, Saudi Arabia.
  • Alswaidan L; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
  • Mardawi G; College of Pharmacy, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Infect Dis Ther ; 10(1): 253-268, 2021 Mar.
Article in English | MEDLINE | ID: covidwho-898177
Semantic information from SemMedBD (by NLM)
1. Anti-Inflammatory Agent TREATS C0439663
Subject
Anti-Inflammatory Agent
Predicate
TREATS
Object
C0439663
2. ibuprofen TREATS Infected
Subject
ibuprofen
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TREATS
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Infected
3. Infected PROCESS_OF Patients
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Infected
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PROCESS_OF
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Patients
4. Anti-Inflammatory Agent TREATS C0030705
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Anti-Inflammatory Agent
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TREATS
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C0030705
5. ibuprofen TREATS Patients
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ibuprofen
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7. Anti-Inflammatory Agents, Non-Steroidal TREATS Infected
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Anti-Inflammatory Agents, Non-Steroidal
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8. ibuprofen TREATS Infected
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9. Infected PROCESS_OF Patients
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10. Anti-Inflammatory Agents, Non-Steroidal TREATS Patients
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Anti-Inflammatory Agents, Non-Steroidal
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11. ibuprofen TREATS Patients
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12. COVID-19 PROCESS_OF Adult
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ABSTRACT

INTRODUCTION:

Ibuprofen disappeared from the pharmacy shelves during the 2019 coronavirus (COVID-19) pandemic. However, a while later, information circulated that ibuprofen should be avoided as it could worsen COVID-19 symptoms. The aim of our study was to assess the association of acute and chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs) with worse COVID-19 outcomes.

METHODS:

We did a prospective cohort study between April 12 and June 1, 2020. Adults consecutively diagnosed with COVID-19 were included. Information on NSAID use was collected through a telephone questionnaire, and patients were followed up for COVID-19 infection outcomes, including death, admission, severity, time to clinical improvement, oxygen requirement and length of stay.

RESULTS:

Acute use of ibuprofen was not associated with a greater risk of mortality relative to non-use (adjusted hazard ratio [HR] 0.632 [95% CI 0.073-5.441; P = 0.6758]). Chronic NSAID use was also not associated with a greater risk of mortality (adjusted HR 0.492 [95% CI 0.178-1.362; P = 0.1721]). Acute ibuprofen use was not associated with a higher risk of admission compared to non-NSAID users (adjusted odds ratio OR 1.271; 95% CI 0.548-2.953). NSAID users did not have a significantly longer time to clinical improvement or length of stay.

CONCLUSION:

Acute or chronic use of ibuprofen and other NSAIDs was not associated with worse COVID-19 disease outcomes.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Language: English Journal: Infect Dis Ther Year: 2021 Document Type: Article Affiliation country: S40121-020-00363-w

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Language: English Journal: Infect Dis Ther Year: 2021 Document Type: Article Affiliation country: S40121-020-00363-w