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Neuromuscular involvement in COVID-19 critically ill patients.
Cabañes-Martínez, Lidia; Villadóniga, Marta; González-Rodríguez, Liliana; Araque, Lesly; Díaz-Cid, Alba; Ruz-Caracuel, Ignacio; Pian, Héctor; Sánchez-Alonso, Susana; Fanjul, Samira; Del Álamo, Marta; Regidor, Ignacio.
  • Cabañes-Martínez L; Clinical Neurophysiology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain. Electronic address: lidia.cabanes@salud.madrid.org.
  • Villadóniga M; Clinical Neurophysiology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
  • González-Rodríguez L; Clinical Neurophysiology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
  • Araque L; Clinical Neurophysiology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
  • Díaz-Cid A; Clinical Neurophysiology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
  • Ruz-Caracuel I; Pathology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain; Research Group in Muscle Regeneration, University of Cordoba, Córdoba, Spain.
  • Pian H; Pathology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
  • Sánchez-Alonso S; Intensive Care Unit, Hospital Universitario Ramón y Cajal, Madrid, Spain.
  • Fanjul S; Neurology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
  • Del Álamo M; Neurosurgery Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
  • Regidor I; Clinical Neurophysiology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Clin Neurophysiol ; 131(12): 2809-2816, 2020 12.
Article in English | MEDLINE | ID: covidwho-898641
ABSTRACT

OBJECTIVE:

Coronavirus disease 2019 (COVID-19) has a high incidence of intensive care admittance due to the severe acute respiratory syndrome (SARS). Intensive care unit (ICU)-acquired weakness (ICUAW) is a common complication of ICU patients consisting of symmetric and generalised weakness. The aim of this study was to determine the presence of myopathy, neuropathy or both in ICU patients affected by COVID-19 and whether ICUAW associated with COVID-19 differs from other aetiologies.

METHODS:

Twelve SARS CoV-2 positive patients referred with the suspicion of critical illness myopathy (CIM) or polyneuropathy (CIP) were included between March and May 2020. Nerve conduction and concentric needle electromyography were performed in all patients while admitted to the hospital. Muscle biopsies were obtained in three patients.

RESULTS:

Four patients presented signs of a sensory-motor axonal polyneuropathy and seven patients showed signs of myopathy. One muscle biopsy showed scattered necrotic and regenerative fibres without inflammatory signs. The other two biopsies showed non-specific myopathic findings.

CONCLUSIONS:

We have not found any distinctive features in the studies of the ICU patients affected by SARS-CoV-2 infection.

SIGNIFICANCE:

Further studies are needed to determine whether COVID-19-related CIM/CIP has different features from other aetiologies. Neurophysiological studies are essential in the diagnosis of these patients.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Polyneuropathies / SARS-CoV-2 / COVID-19 / Intensive Care Units / Muscular Diseases Type of study: Diagnostic study / Etiology study / Observational study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Clin Neurophysiol Journal subject: Neurology / Psychophysiology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Polyneuropathies / SARS-CoV-2 / COVID-19 / Intensive Care Units / Muscular Diseases Type of study: Diagnostic study / Etiology study / Observational study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Clin Neurophysiol Journal subject: Neurology / Psychophysiology Year: 2020 Document Type: Article