A Potential Role of Interleukin 10 in COVID-19 Pathogenesis.

Lu, Ligong; Zhang, Hui; Dauphars, Danielle J; He, You-Wen

Lu, Ligong; Zhang, Hui; Dauphars, Danielle J; He, You-Wen.

Lu L; Zhuhai Interventional Medical Center, Zhuhai Precision Medical Center, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, Guangdong Province, 519000, PR China. Electronic address: luligong1969@126.com.
Zhang H; First Affiliated Hospital, China Medical University, Shenyang, PR China.
Dauphars DJ; Department of Immunology, Duke University Medical University Medical Center, Durham, NC 27710, USA.
He YW; Department of Immunology, Duke University Medical University Medical Center, Durham, NC 27710, USA. Electronic address: youwen.he@duke.edu.

Trends Immunol ; 42(1): 3-5, 2021 01.

Article in English | MEDLINE | ID: covidwho-1065236

ABSTRACT

ABSTRACT

A unique feature of the cytokine storm in coronavirus disease 2019 (COVID-19) is the dramatic elevation of interleukin 10 (IL-10). This was thought to be a negative feedback mechanism to suppress inflammation. However, several lines of clinical evidence suggest that dramatic early proinflammatory IL-10 elevation may play a pathological role in COVID-19 severity.

Subject(s)

COVID-19/immunology; Cytokine Release Syndrome/immunology; Interleukin-10/immunology; SARS-CoV-2/immunology; COVID-19/epidemiology; COVID-19/virology; Cytokine Release Syndrome/metabolism; Epidemics; Humans; Interferon-gamma/immunology; Interferon-gamma/metabolism; Interleukin-10/metabolism; Lymphocytes/immunology; Lymphocytes/metabolism; Models, Immunological; SARS-CoV-2/physiology; Severity of Illness Index

Keywords

COVID-19; IL-10; IL-6; cytokine storm; mortality; pathogenesis; proinflammation

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interleukin-10 / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Trends Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article

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