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Prognostic Impact of Prior Heart Failure in Patients Hospitalized With COVID-19.
Alvarez-Garcia, Jesus; Lee, Samuel; Gupta, Arjun; Cagliostro, Matthew; Joshi, Aditya A; Rivas-Lasarte, Mercedes; Contreras, Johanna; Mitter, Sumeet S; LaRocca, Gina; Tlachi, Pilar; Brunjes, Danielle; Glicksberg, Benjamin S; Levin, Matthew A; Nadkarni, Girish; Fayad, Zahi; Fuster, Valentin; Mancini, Donna; Lala, Anuradha.
  • Alvarez-Garcia J; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Cardiology Department, Hospital de la Santa Creu i Sant Pau, IIb-SantPau, CIBERCV, Universitat Autónoma de Barcelona, Barcelona, Spain. Electronic address: https://twitter.com/j_alva
  • Lee S; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Gupta A; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Cagliostro M; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Joshi AA; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Rivas-Lasarte M; Cardiology Department, Hospital de la Santa Creu i Sant Pau, IIb-SantPau, CIBERCV, Universitat Autónoma de Barcelona, Barcelona, Spain.
  • Contreras J; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Mitter SS; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • LaRocca G; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Tlachi P; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Brunjes D; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Glicksberg BS; The Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; The Mount Sinai Clinical Intelligence Center, New York, New York.
  • Levin MA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Institute for Healthcare Delivery Science, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at
  • Nadkarni G; The Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York; The Mount Sinai Clinical Intelligence Center, New York, New York; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; Charles Bronfman Institute for Personalized Medicine, Icahn Schoo
  • Fayad Z; The BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Fuster V; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
  • Mancini D; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Lala A; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: anu.lala@mountsinai.org.
J Am Coll Cardiol ; 76(20): 2334-2348, 2020 11 17.
Article in English | MEDLINE | ID: covidwho-899039
ABSTRACT

BACKGROUND:

Patients with pre-existing heart failure (HF) are likely at higher risk for adverse outcomes in coronavirus disease-2019 (COVID-19), but data on this population are sparse.

OBJECTIVES:

This study described the clinical profile and associated outcomes among patients with HF hospitalized with COVID-19.

METHODS:

This study conducted a retrospective analysis of 6,439 patients admitted for COVID-19 at 1 of 5 Mount Sinai Health System hospitals in New York City between February 27 and June 26, 2020. Clinical characteristics and outcomes (length of stay, need for intensive care unit, mechanical ventilation, and in-hospital mortality) were captured from electronic health records. For patients identified as having a history of HF by International Classification of Diseases-9th and/or 10th Revisions codes, manual chart abstraction informed etiology, functional class, and left ventricular ejection fraction (LVEF).

RESULTS:

Mean age was 63.5 years, and 45% were women. Compared with patients without HF, those with previous HF experienced longer length of stay (8 days vs. 6 days; p < 0.001), increased risk of mechanical ventilation (22.8% vs. 11.9%; adjusted odds ratio 3.64; 95% confidence interval 2.56 to 5.16; p < 0.001), and mortality (40.0% vs. 24.9%; adjusted odds ratio 1.88; 95% confidence interval 1.27 to 2.78; p = 0.002). Outcomes among patients with HF were similar, regardless of LVEF or renin-angiotensin-aldosterone inhibitor use.

CONCLUSIONS:

History of HF was associated with higher risk of mechanical ventilation and mortality among patients hospitalized for COVID-19, regardless of LVEF.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Heart Failure / Hospitalization Type of study: Cohort study / Diagnostic study / Etiology study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: J Am Coll Cardiol Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Heart Failure / Hospitalization Type of study: Cohort study / Diagnostic study / Etiology study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: J Am Coll Cardiol Year: 2020 Document Type: Article