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Possible application of high-dose vitamin C in the prevention and therapy of coronavirus infection.
Hoang, Ba X; Shaw, Graeme; Fang, Willian; Han, Bo.
  • Hoang BX; Nimni-Cordoba Tissue Engineering and Drug Discovery Laboratory, Department of Surgery, University of Southern California, Los Angeles, California, USA.
  • Shaw G; Integrative Medical Associates, Foster City, California, USA.
  • Fang W; Western University of Health Sciences, Pomona, California, USA.
  • Han B; Nimni-Cordoba Tissue Engineering and Drug Discovery Laboratory, Department of Surgery, University of Southern California, Los Angeles, California, USA. Electronic address: bohan@usc.edu.
J Glob Antimicrob Resist ; 23: 256-262, 2020 12.
Article in English | MEDLINE | ID: covidwho-899142
Semantic information from SemMedBD (by NLM)
1. Communicable Diseases ASSOCIATED_WITH Pathogenic organism
Subject
Communicable Diseases
Predicate
ASSOCIATED_WITH
Object
Pathogenic organism
2. Antiviral Agents TREATS Genus: Coronavirus
Subject
Antiviral Agents
Predicate
TREATS
Object
Genus: Coronavirus
3. Adrenal Cortex Hormones COMPLICATES Disease Progression
Subject
Adrenal Cortex Hormones
Predicate
COMPLICATES
Object
Disease Progression
4. Antiviral Agents COMPLICATES Disease Progression
Subject
Antiviral Agents
Predicate
COMPLICATES
Object
Disease Progression
5. Anti-Bacterial Agents COMPLICATES Disease Progression
Subject
Anti-Bacterial Agents
Predicate
COMPLICATES
Object
Disease Progression
6. ascorbic acid PREVENTS Virus Diseases
Subject
ascorbic acid
Predicate
PREVENTS
Object
Virus Diseases
7. Disease Progression AFFECTS Complication
Subject
Disease Progression
Predicate
AFFECTS
Object
Complication
8. Communicable Diseases ASSOCIATED_WITH Pathogenic organism
Subject
Communicable Diseases
Predicate
ASSOCIATED_WITH
Object
Pathogenic organism
9. Antiviral Agents TREATS Genus: Coronavirus
Subject
Antiviral Agents
Predicate
TREATS
Object
Genus: Coronavirus
10. Adrenal Cortex Hormones COMPLICATES Disease Progression
Subject
Adrenal Cortex Hormones
Predicate
COMPLICATES
Object
Disease Progression
11. Antiviral Agents COMPLICATES Disease Progression
Subject
Antiviral Agents
Predicate
COMPLICATES
Object
Disease Progression
12. Anti-Bacterial Agents COMPLICATES Disease Progression
Subject
Anti-Bacterial Agents
Predicate
COMPLICATES
Object
Disease Progression
13. ascorbic acid PREVENTS Virus Diseases
Subject
ascorbic acid
Predicate
PREVENTS
Object
Virus Diseases
14. Disease Progression AFFECTS Complication
Subject
Disease Progression
Predicate
AFFECTS
Object
Complication
ABSTRACT
Coronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses increase oxidative stress in the body leading to cellular and tissue damage. To combat this, administration of high-dose vitamin C (ascorbic acid or ascorbate), in addition to standard conventional supportive treatments, has been shown to be a safe and effective therapy for severe cases of respiratory viral infection. Morbidity, mortality, infectiveness and spread of infectious diseases are dependent on the host-pathogen relationship. Given the lack of effective and safe antiviral drugs for coronaviruses, there should be more attention in supporting host immune defence, cytoprotection and immunoregulation. Implementation of high-dose vitamin C therapy could dramatically reduce the need for high doses of corticosteroids, antibacterials and antiviral drugs that may be immunosuppressive, adrenal depressive and toxic, complicating the disease course. In order to effectively fight the novel SARS-CoV-2 virus, medical professionals should explore readily available pharmaceutical and nutritional therapeutic agents with proven antioxidant, anti-inflammatory and immunosupportive properties. Supplemental vitamin C may also provide additional benefits for the prevention of viral infections, shorten the disease course and lessen complications of the disease.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Ascorbic Acid / Coronavirus Infections Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: J Glob Antimicrob Resist Year: 2020 Document Type: Article Affiliation country: J.jgar.2020.09.025

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ascorbic Acid / Coronavirus Infections Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: J Glob Antimicrob Resist Year: 2020 Document Type: Article Affiliation country: J.jgar.2020.09.025