Immunity after COVID-19: Protection or sensitization?
Math Biosci
; 331: 108499, 2021 01.
Article
in English
| MEDLINE | ID: covidwho-899298
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
ABSTRACT
Motivated by historical and present clinical observations, we discuss the possible unfavorable evolution of the immunity (similar to documented antibody-dependent enhancement scenarios) after a first infection with COVID-19. More precisely we ask the question of how the epidemic outcomes are affected if the initial infection does not provide immunity but rather sensitization to future challenges. We first provide background comparison with the 2003 SARS epidemic. Then we use a compartmental epidemic model structured by immunity level that we fit to available data; using several scenarios of the fragilization dynamics, we derive quantitative insights into the additional expected numbers of severe cases and deaths.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antibody-Dependent Enhancement
/
Reinfection
/
COVID-19
/
Models, Biological
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Math Biosci
Year:
2021
Document Type:
Article
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