A natural food preservative peptide nisin can interact with the SARS-CoV-2 spike protein receptor human ACE2.
Virology
; 552: 107-111, 2021 01 02.
Article
in English
| MEDLINE | ID: covidwho-899647
ABSTRACT
Nisin, a food-grade antimicrobial peptide produced by lactic acid bacteria has been examined for its probable interaction with the human ACE2 (hACE2) receptor, the site where spike protein of SARS-CoV-2 binds. Among the eight nisin variants examined, nisin H, nisin Z, nisin U and nisin A showed a significant binding affinity towards hACE2, higher than that of the RBD (receptor binding domain) of the SARS-CoV-2 spike protein. The molecular interaction of nisin with hACE2 was investigated by homology modeling and docking studies. Further, binding efficiency of the most potent nisin H was evaluated through the interaction of hACE2nisin H complex with RBD (receptor-binding domain) of SARS-CoV-2 and that of hACE2RBD complex with nisin H. Here, nisin H acted as a potential competitor of RBD to access the hACE2 receptor. The study unravels for the first time that a globally used food preservative, nisin has the potential to bind to hACE2.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Receptors, Virus
/
Spike Glycoprotein, Coronavirus
/
Angiotensin-Converting Enzyme 2
/
Nisin
Type of study:
Experimental Studies
Topics:
Variants
Limits:
Humans
Language:
English
Journal:
Virology
Year:
2021
Document Type:
Article
Affiliation country:
J.virol.2020.10.002
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