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SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19.
Anderson, Elizabeth M; Diorio, Caroline; Goodwin, Eileen C; McNerney, Kevin O; Weirick, Madison E; Gouma, Sigrid; Bolton, Marcus J; Arevalo, Claudia P; Chase, Julie; Hicks, Philip; Manzoni, Tomaz B; Baxter, Amy E; Andrea, Kurt P; Burudpakdee, Chakkapong; Lee, Jessica H; Vella, Laura A; Henrickson, Sarah E; Harris, Rebecca M; Wherry, E John; Bates, Paul; Bassiri, Hamid; Behrens, Edward M; Teachey, David T; Hensley, Scott E.
  • Anderson EM; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
  • Diorio C; These authors contributed equally to this work: Elizabeth M. Anderson and Caroline Diorio.
  • Goodwin EC; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • McNerney KO; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Weirick ME; These authors contributed equally to this work: Elizabeth M. Anderson and Caroline Diorio.
  • Gouma S; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
  • Bolton MJ; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Arevalo CP; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Chase J; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
  • Hicks P; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
  • Manzoni TB; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
  • Baxter AE; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
  • Andrea KP; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Burudpakdee C; Division of Rheumatology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Lee JH; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
  • Vella LA; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA USA.
  • Henrickson SE; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
  • Harris RM; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Wherry EJ; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
  • Bates P; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Bassiri H; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
  • Behrens EM; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Teachey DT; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Hensley SE; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
medRxiv ; 2020 Aug 18.
Article in English | MEDLINE | ID: covidwho-900749
Preprint
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Semantic information from SemMedBD (by NLM)
1. Antibody Formation PROCESS_OF Child
Subject
Antibody Formation
Predicate
PROCESS_OF
Object
Child
2. Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects PROCESS_OF Child
Subject
Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects
Predicate
PROCESS_OF
Object
Child
3. Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects PROCESS_OF Patients
Subject
Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects
Predicate
PROCESS_OF
Object
Patients
4. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
5. Antibody Formation PROCESS_OF Child
Subject
Antibody Formation
Predicate
PROCESS_OF
Object
Child
6. Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects PROCESS_OF Child
Subject
Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects
Predicate
PROCESS_OF
Object
Child
7. Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects PROCESS_OF Patients
Subject
Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects
Predicate
PROCESS_OF
Object
Patients
8. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
SARS-CoV-2 antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike IgG titers compared to those with severe coronavirus disease 2019 (COVID-19), likely reflecting a longer time since onset of infection in MIS-C patients.

Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2020 Document Type: Article