Your browser doesn't support javascript.
Evaluation of a SARS-CoV-2 Surrogate Virus Neutralization Test for Detection of Antibody in Human, Canine, Cat, and Hamster Sera.
Perera, Ranawaka A P M; Ko, Ronald; Tsang, Owen T Y; Hui, David S C; Kwan, Mike Y M; Brackman, Christopher J; To, Esther M W; Yen, Hui-Ling; Leung, Kathy; Cheng, Samuel M S; Chan, Kin Ho; Chan, Karl C K; Li, Ka-Chi; Saif, Linda; Barrs, Vanessa R; Wu, Joseph T; Sit, Thomas H C; Poon, Leo L M; Peiris, Malik.
  • Perera RAPM; School of Public Health, The University of Hong Kong, Pok Fu Lam, Hong Kong Special Administrative Region, China.
  • Ko R; School of Public Health, The University of Hong Kong, Pok Fu Lam, Hong Kong Special Administrative Region, China.
  • Tsang OTY; Infectious Diseases Centre, Princess Margaret Hospital, Hospital Authority of Hong Kong, Kwai Chung, Hong Kong Special Administrative Region, China.
  • Hui DSC; Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Kwan MYM; Department of Paediatric and Adolescent Medicine, Princess Margaret Hospital, Hospital Authority of Hong Kong, Kwai Chung, Hong Kong Special Administrative Region, China.
  • Brackman CJ; Agriculture, Fisheries and Conservation Department, Government of the Hong Kong Special Administrative Region, Hong Kong Special Administrative Region, China.
  • To EMW; Agriculture, Fisheries and Conservation Department, Government of the Hong Kong Special Administrative Region, Hong Kong Special Administrative Region, China.
  • Yen HL; School of Public Health, The University of Hong Kong, Pok Fu Lam, Hong Kong Special Administrative Region, China.
  • Leung K; School of Public Health, The University of Hong Kong, Pok Fu Lam, Hong Kong Special Administrative Region, China.
  • Cheng SMS; Laboratory of Data Discovery for Health (D4H), New Territories, Hong Kong Special Administrative Region, China.
  • Chan KH; School of Public Health, The University of Hong Kong, Pok Fu Lam, Hong Kong Special Administrative Region, China.
  • Chan KCK; School of Public Health, The University of Hong Kong, Pok Fu Lam, Hong Kong Special Administrative Region, China.
  • Li KC; School of Public Health, The University of Hong Kong, Pok Fu Lam, Hong Kong Special Administrative Region, China.
  • Saif L; School of Public Health, The University of Hong Kong, Pok Fu Lam, Hong Kong Special Administrative Region, China.
  • Barrs VR; Food Animal Health Research Program, OARDC/The Ohio State University, Wooster, Ohio, USA.
  • Wu JT; Jockey Club College of Veterinary Medicine & Life Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong Special Administrative Region, China.
  • Sit THC; School of Public Health, The University of Hong Kong, Pok Fu Lam, Hong Kong Special Administrative Region, China.
  • Poon LLM; Laboratory of Data Discovery for Health (D4H), New Territories, Hong Kong Special Administrative Region, China.
  • Peiris M; Agriculture, Fisheries and Conservation Department, Government of the Hong Kong Special Administrative Region, Hong Kong Special Administrative Region, China.
J Clin Microbiol ; 59(2)2021 01 21.
Article in English | MEDLINE | ID: covidwho-1043639
ABSTRACT
Surrogate neutralization assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that can be done without biosafety level 3 containment and in multiple species are desirable. We evaluate a recently developed surrogate virus neutralization test (sVNT) in comparison to 90% plaque reduction neutralization tests (PRNT90) in human, canine, cat, and hamster sera. With PRNT90 as the reference, sVNT had sensitivity of 98.9% and specificity of 98.8%. Using a panel of immune sera corresponding to other coronaviruses, we confirm the lack of cross-reactivity to other coronaviruses in SARS-CoV-2 sVNT and PRNT90, except for cross-reactivity to SARS-CoV-1 in sVNT.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Neutralization Tests / COVID-19 Serological Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Randomized controlled trials Limits: Animals / Female / Humans / Male Language: English Year: 2021 Document Type: Article Affiliation country: JCM.02504-20

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Neutralization Tests / COVID-19 Serological Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Randomized controlled trials Limits: Animals / Female / Humans / Male Language: English Year: 2021 Document Type: Article Affiliation country: JCM.02504-20