A Covid-19 Patient with Complement-Mediated Coagulopathy and Severe Thrombosis.
Pathobiology
; 88(1): 28-36, 2021.
Article
in English
| MEDLINE | ID: covidwho-901505
ABSTRACT
We report a patient with severe Covid-19-associated coagulopathy and type 2 diabetes mellitus who tested positive for antiphospholipid antibodies (aPL). Analysis of skin specimens suggested direct SARS-CoV-2 viral-induced and complement-mediated vascular injury and thrombosis, consistent with prior reports. Serial aPL testing demonstrated high levels of anticardiolipin antibodies (aCL) that declined to insignificant levels over a period of 5 weeks. SARS-CoV-2 RNA was detected in nasopharyngeal swab specimens on serial assays performed over the same 5-week period, though it was not detected thereafter. We hypothesize that SARS-CoV-2 viral-induced aPL contributed to severe Covid-19-associated coagulopathy in this patient.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Thrombosis
/
Diabetes Mellitus, Type 2
/
SARS-CoV-2
/
COVID-19
Type of study:
Case report
/
Diagnostic study
Topics:
Long Covid
Limits:
Female
/
Humans
/
Middle aged
Language:
English
Journal:
Pathobiology
Journal subject:
Pathology
Year:
2021
Document Type:
Article
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