The divergence between SARS-CoV-2 and RaTG13 might be overestimated due to the extensive RNA modification
Future Virology
; 15(6):341-347, 2020.
Article
in English
| Web of Science | ID: covidwho-902297
ABSTRACT
Aim:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. There is urgent need to understand the phylogeny, divergence and origin of SARS-CoV-2. Materials &methods:
A recent study claimed that there was 17% divergence between SARS-CoV-2 and RaTG13 (a SARS-related coronaviruses) on synonymous sites by using sequence alignment. We re-analyzed the sequences of the two coronaviruses with the same methodology.Results:
We found that 87% of the synonymous substitutions between the two coronaviruses could be potentially explained by the RNA modification system in hosts, with 65% contributed by deamination on cytidines (C-T mismatches) and 22% contributed by deamination on adenosines (A-G mismatches).Conclusion:
Our results demonstrate that the divergence between SARS-CoV-2 and RaTG13 has been overestimated.
Full text:
Available
Collection:
Databases of international organizations
Database:
Web of Science
Language:
English
Journal:
Future Virology
Year:
2020
Document Type:
Article
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