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Detecting Progression of Melanocytic Choroidal Tumors by Sequential Imaging: Is Ultrasonography Necessary?
Roelofs, Kelsey A; O'Day, Roderick; Al Harby, Lamis; Hay, Gordon; Arora, Amit K; Cohen, Victoria M L; Sagoo, Mandeep S; Damato, Bertil E.
  • Roelofs KA; Ocular Oncology Service, Moorfields Eye Hospital, London EC1V 2PD, UK.
  • O'Day R; Ocular Oncology Service, Moorfields Eye Hospital, London EC1V 2PD, UK.
  • Al Harby L; Department of Ophthalmology, Ocular Oncology Clinic, Royal Victorian Eye and Ear Hospital, Melbourne 3002, Australia.
  • Hay G; Ocular Oncology Service, Moorfields Eye Hospital, London EC1V 2PD, UK.
  • Arora AK; Ocular Oncology Service, Moorfields Eye Hospital, London EC1V 2PD, UK.
  • Cohen VML; NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London EC1V 9EL, UK.
  • Sagoo MS; Ocular Oncology Service, Moorfields Eye Hospital, London EC1V 2PD, UK.
  • Damato BE; NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London EC1V 9EL, UK.
Cancers (Basel) ; 12(7)2020 Jul 10.
Article in English | MEDLINE | ID: covidwho-902478
ABSTRACT

Purpose:

To determine if ultrasonography is necessary to detect progression of choroidal melanocytic tumors undergoing sequential multi-modal imaging with color photography, autofluorescence (AF) and optical coherence tomography (OCT).

Methods:

All patients with choroidal melanoma undergoing treatment at Moorfields Eye Hospital between January 2016 and March 2020 were reviewed to identify those with treatment deferred by ≥2 months. Tumors that showed progression prior to treatment, defined as an increase in (a) basal dimensions (b) thickness (c) orange pigment and/or (d) sub-retinal fluid, were included. Mushroom shape, Orange pigment, Large size, Enlargement and Sub-retinal fluid (MOLES) scores were assigned to all tumors at earliest date and date of treatment.

Results:

A total of 99 patients with a mean age of 66 years (range 26-90) were included. The initial MOLES score was 1 in 2 cases, 2 in 23 cases, and ≥3 in 74 cases. Progression was detected with sequential color photography alone in 100% of MOLES 1/2 and 97% of lesions with a MOLES score of ≥3. When findings on AF and OCT were included, sensitivity for detecting subtle change without ultrasonography improved to 100% for MOLES 3 and 97% for MOLES 4/5. Only one patient included in this study had an isolated increase in thickness that may have been missed had sequential ultrasonography not been performed. Overall, the sensitivity for detecting progression with color photographs alone was 97% (95% CI 93-100%) and increased to 99% (95% CI 97-100%) by including autofluorescence and OCT.

Conclusions:

Monitoring of choroidal nevi, particularly those classified as MOLES 1 or 2 (i.e., low-risk or high-risk naevi), can be accomplished safely without the need for ultrasonography. The findings of this study may remove barriers to the implementation of tele-oncology clinics for the monitoring of choroidal melanocytic tumors.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Prognostic study Language: English Year: 2020 Document Type: Article Affiliation country: Cancers12071856

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Prognostic study Language: English Year: 2020 Document Type: Article Affiliation country: Cancers12071856