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[Mesenchymal stem cells in the treatment of COVID-19-progress and challenges].
Wang, Jiayi; Zou, Wei; Liu, Jing.
  • Wang J; Stem Cell Clinical Research Institute, the First Affiliated Hospital of Dalian Medical University, Dalian 116000, Liaoning, China.
  • Zou W; Dalian Stem Cell and Precision Medicine Innovation Institute, Dalian 116000, Liaoning, China.
  • Liu J; Dalian Stem Cell and Precision Medicine Innovation Institute, Dalian 116000, Liaoning, China.
Sheng Wu Gong Cheng Xue Bao ; 36(10): 1970-1978, 2020 Oct 25.
Article in Chinese | MEDLINE | ID: covidwho-903032
Semantic information from SemMedBD (by NLM)
1. Confirmation PROCESS_OF Patients
Subject
Confirmation
Predicate
PROCESS_OF
Object
Patients
2. Structure of parenchyma of lung LOCATION_OF Wound Healing
Subject
Structure of parenchyma of lung
Predicate
LOCATION_OF
Object
Wound Healing
3. Anti-Inflammatory Agents PREVENTS Cytokine Storm
Subject
Anti-Inflammatory Agents
Predicate
PREVENTS
Object
Cytokine Storm
4. Coronavirus Infections PROCESS_OF Patients
Subject
Coronavirus Infections
Predicate
PROCESS_OF
Object
Patients
5. Coronavirus Infections CAUSES Cytokine Storm
Subject
Coronavirus Infections
Predicate
CAUSES
Object
Cytokine Storm
6. Confirmation PROCESS_OF Patients
Subject
Confirmation
Predicate
PROCESS_OF
Object
Patients
7. Structure of parenchyma of lung LOCATION_OF Wound Healing
Subject
Structure of parenchyma of lung
Predicate
LOCATION_OF
Object
Wound Healing
8. Anti-Inflammatory Agents PREVENTS Cytokine Storm
Subject
Anti-Inflammatory Agents
Predicate
PREVENTS
Object
Cytokine Storm
9. Coronavirus Infections PROCESS_OF Patients
Subject
Coronavirus Infections
Predicate
PROCESS_OF
Object
Patients
10. Coronavirus Infections CAUSES Cytokine Storm
Subject
Coronavirus Infections
Predicate
CAUSES
Object
Cytokine Storm
ABSTRACT
At present, SARS-CoV-2 is raging, and novel coronavirus pneumonia (COVID-19) has caused more than 35 million confirmed patients and more than 500 000 cases death, which seriously endanger human health, socioeconomic development, as well as global medical and public health systems. COVID-19 is highly contagious, has a long incubation period, and causes many death cases due to lack of effective specific treatment. Mesenchymal stem cells have powerful anti-inflammatory and immunoregulatory functions, and can effectively reduce the cytokine storm caused by coronavirus in patients, and improve the pulmonary fibrosis of patients, promote the repair of damaged lung tissue, and reduce the mortality. Currently, a number of related clinical trials of mesenchymal stem cell treatment of COVID-19 have been conducted, and have confirmed the safety and efficacy, suggesting a good clinical application prospect. While progress has been made in mesenchymal stem cell therapy for COVID-19, we should also catch sight of the problems and challenges faced by mesenchymal stem cell clinical trials under severe epidemic situation, including clinical trials design, stem cell quality management, and ethics in treatment. Only by paying attention to these can we guarantee the safe and effective development of mesenchymal stem cell clinical trials in the treatment of COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Mesenchymal Stem Cell Transplantation / Mesenchymal Stem Cells Type of study: Randomized controlled trials Limits: Humans Language: Chinese Journal: Sheng Wu Gong Cheng Xue Bao Journal subject: Biotechnology Year: 2020 Document Type: Article Affiliation country: J.cjb.200216

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Mesenchymal Stem Cell Transplantation / Mesenchymal Stem Cells Type of study: Randomized controlled trials Limits: Humans Language: Chinese Journal: Sheng Wu Gong Cheng Xue Bao Journal subject: Biotechnology Year: 2020 Document Type: Article Affiliation country: J.cjb.200216