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A Possible Path towards Rapid Development of Live-Attenuated SARS-CoV-2 Vaccines: Plunging into the Natural Pool.
Todorov, German; Uversky, Vladimir N.
  • Todorov G; Emotional Brain Institute, Nathan Kline Institute, Orangeburg, NY 10962, USA.
  • Uversky VN; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Biomolecules ; 10(10)2020 10 14.
Article in English | MEDLINE | ID: covidwho-906422
ABSTRACT
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19) pandemic spreading around the world, causing massive distress to the world's economy and affecting healthcare systems worldwide. Although some exposed individuals have no symptoms and most symptomatic infections are not severe, COVID-19 cases span a wide spectrum, ranging from mild to critical and sometimes resulting in life-threatening complications, such as pneumonia, severe respiratory distress and cardiac problems. Currently, there is no curative drug for COVID-19 and vaccines are still under development. We are presenting here a strategy for the fast development of natural live-attenuated SARS-CoV-2 vaccines. Our proposed approach is based on screening for, identifying, analyzing and selecting naturally attenuated yet highly immunogenic SARS-CoV-2 strains, which may lead to a shorter cycle of vaccine development, as well as higher vaccine effectiveness.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Vaccines, Attenuated / Viral Vaccines / Coronavirus Infections Type of study: Observational study Topics: Vaccines Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Biom10101438

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Vaccines, Attenuated / Viral Vaccines / Coronavirus Infections Type of study: Observational study Topics: Vaccines Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Biom10101438