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The importance of naturally attenuated SARS-CoV-2in the fight against COVID-19.
Armengaud, Jean; Delaunay-Moisan, Agnès; Thuret, Jean-Yves; van Anken, Eelco; Acosta-Alvear, Diego; Aragón, Tomás; Arias, Carolina; Blondel, Marc; Braakman, Ineke; Collet, Jean-François; Courcol, René; Danchin, Antoine; Deleuze, Jean-François; Lavigne, Jean-Philippe; Lucas, Sophie; Michiels, Thomas; Moore, Edward R B; Nixon-Abell, Jonathon; Rossello-Mora, Ramon; Shi, Zheng-Li; Siccardi, Antonio G; Sitia, Roberto; Tillett, Daniel; Timmis, Kenneth N; Toledano, Michel B; van der Sluijs, Peter; Vicenzi, Elisa.
  • Armengaud J; Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SPI, Bagnols-sur-Cèze, 30200, France.
  • Delaunay-Moisan A; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, 91198, France.
  • Thuret JY; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, 91198, France.
  • van Anken E; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Università Vita-Salute San Raffaele, Via Olgettina 58, Milan, 20132, Italy.
  • Acosta-Alvear D; Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.
  • Aragón T; Center for Applied Medical Research, Department of Gene Therapy and Regulation of Gene Expression, University of Navarra, 55 Pio XII Street, Pamplona, 31008, Spain.
  • Arias C; Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.
  • Blondel M; Institut National de la Santé et de la Recherche Médicale UMR1078, 22 Avenue Camille Desmoulins, Brest, F-29200, France.
  • Braakman I; Université de Bretagne Occidentale, Faculté de Médecine et des Sciences de la Santé, 22 Avenue Camille Desmoulins, Brest, F-29200, France.
  • Collet JF; Etablissement Français du Sang (EFS) Bretagne, Brest, F-29200, France.
  • Courcol R; CHRU Brest, Hôpital Morvan, Laboratoire de Génétique Moléculaire, 22 Avenue Camille Desmoulins, Brest, F-29200, France.
  • Danchin A; Cellular Protein Chemistry, Bijvoet Centre for Biomolecular Science, Science for Life, Utrecht University, The Netherlands.
  • Deleuze JF; de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
  • Lavigne JP; WELBIO, Wallonia, Belgium.
  • Lucas S; Expertise France, 73 Avenue de Vaugirard, Paris, 75006, France.
  • Michiels T; Stellate Therapeutics/Kodikos, Institut Cochin, Paris, 75014, France.
  • Moore ERB; Centre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, CEA, Université Paris-Saclay, Evry, 91057, France.
  • Nixon-Abell J; U1047, Institut National de la Santé et de la Recherche Médicale, Université Montpellier, Montpellier, France.
  • Rossello-Mora R; Service de Microbiologie et Hygiène Hospitalière, CHU Nîmes, Nîmes, France.
  • Shi ZL; de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
  • Siccardi AG; WELBIO, Wallonia, Belgium.
  • Sitia R; de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
  • Tillett D; Department of Infectious Diseases, Institute for Biomedicine, Sahlgrenska Academy of the University of Gothenburg, Gothenburg, SE-41346, Sweden.
  • Timmis KN; Department of Clinical Microbiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, SE-41346, Sweden.
  • Toledano MB; Department of Clinical Neurosciences, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK.
  • van der Sluijs P; Marine Microbiology Group, Department of Animal and Bacterial Diversity, IMEDEA (CSIC-UIB), Esporles, Balearic Islands, 07190, Spain.
  • Vicenzi E; CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People's Republic of China.
Environ Microbiol ; 22(6): 1997-2000, 2020 06.
Article in English | MEDLINE | ID: covidwho-908149
ABSTRACT
The current SARS-CoV-2 pandemic is wreaking havoc throughout the world and has rapidly become a global health emergency. A central question concerning COVID-19 is why some individuals become sick and others not. Many have pointed already at variation in risk factors between individuals. However, the variable outcome of SARS-CoV-2 infections may, at least in part, be due also to differences between the viral subspecies with which individuals are infected. A more pertinent question is how we are to overcome the current pandemic. A vaccine against SARS-CoV-2 would offer significant relief, although vaccine developers have warned that design, testing and production of vaccines may take a year if not longer. Vaccines are based on a handful of different designs (i), but the earliest vaccines were based on the live, attenuated virus. As has been the case for other viruses during earlier pandemics, SARS-CoV-2 will mutate and may naturally attenuate over time (ii). What makes the current pandemic unique is that, thanks to state-of-the-art nucleic acid sequencing technologies, we can follow in detail how SARS-CoV-2 evolves while it spreads. We argue that knowledge of naturally emerging attenuated SARS-CoV-2 variants across the globe should be of key interest in our fight against the pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severe acute respiratory syndrome-related coronavirus / Betacoronavirus Type of study: Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal: Environ Microbiol Journal subject: Microbiology / Environmental Health Year: 2020 Document Type: Article Affiliation country: 1462-2920.15039

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severe acute respiratory syndrome-related coronavirus / Betacoronavirus Type of study: Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal: Environ Microbiol Journal subject: Microbiology / Environmental Health Year: 2020 Document Type: Article Affiliation country: 1462-2920.15039