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Determine the Potential Epitope Based Peptide Vaccine Against Novel SARS-CoV-2 Targeting Structural Proteins Using Immunoinformatics Approaches.
Waqas, Muhammad; Haider, Ali; Sufyan, Muhammad; Siraj, Sami; Sehgal, Sheikh Arslan.
  • Waqas M; Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Faisalabad, Pakistan.
  • Haider A; Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Faisalabad, Pakistan.
  • Sufyan M; Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Faisalabad, Pakistan.
  • Siraj S; Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan.
  • Sehgal SA; Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Faisalabad, Pakistan.
Front Mol Biosci ; 7: 227, 2020.
Article in English | MEDLINE | ID: covidwho-908334
ABSTRACT
Coronaviruses (CoVs) belong to the Coronaviridae-family. The genus Beta-coronaviruses, are enveloped positive strand RNA viruses with club-like spikes at the surface with a unique replication process and a large RNA genome (∼25 kb). CoVs are known as one of the major pathogenic viruses causing a variety of diseases in birds and mammals including humans (lethal respiratory dysfunctions). Recently, a new strain of coronavirus has been identified and named as SARS-CoV-2. A large number of COVID-19 (disease caused by SARS-CoV-2) cases are being diagnosed all over the World especially in China (Wuhan). COVID-19 showed high mortality rate exponentially, however, not even a single effective cure is being introduced yet against COVID-19. In the current study, immunoinformatics approaches were employed to predict the antigenic epitopes against COVID-19 for the development of a coronavirus peptide vaccine. Cytotoxic T-lymphocyte (CTL) and B-cell epitopes were predicted for SARS-CoV-2 coronavirus structural proteins (Spikes, Membrane, Envelope, and Nucleocapsid). The docking complexes of the top 10 epitopes having antigenic sites were analyzed led by binding affinity and binding interactional analyses of top ranked predicted peptides with the MHC-I HLA molecule. The predicted peptides may have potential to be used as peptide vaccine against COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Journal: Front Mol Biosci Year: 2020 Document Type: Article Affiliation country: Fmolb.2020.00227

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Journal: Front Mol Biosci Year: 2020 Document Type: Article Affiliation country: Fmolb.2020.00227