Your browser doesn't support javascript.
Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy.
Balestrini, Simona; Koepp, Matthias J; Gandhi, Sonia; Rickman, Hannah M; Shin, Gee Yen; Houlihan, Catherine F; Anders-Cannon, Jonny; Silvennoinen, Katri; Xiao, Fenglai; Zagaglia, Sara; Hudgell, Kirsty; Ziomek, Mariusz; Haimes, Paul; Sampson, Adam; Parker, Annie; Helen Cross, J; Pardington, Rosemarie; Nastouli, Eleni; Swanton, Charles; Sander, Josemir W; Sisodiya, Sanjay M.
  • Balestrini S; Department of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK; Chalfont Centre for Epilepsy (CCE), Chalfont St Peter, Bucks SL9 0RJ, UK.
  • Koepp MJ; Department of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK; Chalfont Centre for Epilepsy (CCE), Chalfont St Peter, Bucks SL9 0RJ, UK. Electronic address: m.koepp@ucl.ac.uk.
  • Gandhi S; The Francis Crick Institute, London NW1 1AT, UK; UCL Cancer Institute, London WC1E 6DD, UK; Department of Virology, University College London Hospitals, NHS Foundation Trust, London NW1 2PG, UK.
  • Rickman HM; Department of Virology, University College London Hospitals, NHS Foundation Trust, London NW1 2PG, UK.
  • Shin GY; Department of Virology, University College London Hospitals, NHS Foundation Trust, London NW1 2PG, UK.
  • Houlihan CF; Department of Virology, University College London Hospitals, NHS Foundation Trust, London NW1 2PG, UK.
  • Anders-Cannon J; Chalfont Centre for Epilepsy (CCE), Chalfont St Peter, Bucks SL9 0RJ, UK.
  • Silvennoinen K; Department of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
  • Xiao F; Department of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
  • Zagaglia S; Department of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
  • Hudgell K; St. Elizabeth (STE), Much Hadham, Herts SG106EW, UK.
  • Ziomek M; St. Elizabeth (STE), Much Hadham, Herts SG106EW, UK.
  • Haimes P; St. Elizabeth (STE), Much Hadham, Herts SG106EW, UK.
  • Sampson A; St. Elizabeth (STE), Much Hadham, Herts SG106EW, UK.
  • Parker A; The Meath (TM), Westbrook Road, Godalming GU7 2QH, UK.
  • Helen Cross J; Great Ormond Street Hospital (GOSH) and UCL Institute of Child Health, WC1N 1EH, UK; Young Epilepsy (YE), Surrey RH7 6PW, UK.
  • Pardington R; Young Epilepsy (YE), Surrey RH7 6PW, UK.
  • Nastouli E; Department of Virology, University College London Hospitals, NHS Foundation Trust, London NW1 2PG, UK; Department of Population, Policy and Practice, UCL GOS Institute of Child Health, London WC1N 1EH, UK.
  • Swanton C; The Francis Crick Institute, London NW1 1AT, UK; UCL Cancer Institute, London WC1E 6DD, UK; Department of Virology, University College London Hospitals, NHS Foundation Trust, London NW1 2PG, UK.
  • Sander JW; Department of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK; Chalfont Centre for Epilepsy (CCE), Chalfont St Peter, Bucks SL9 0RJ, UK; Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, The Netherlands. Electronic address: l.sander@ucl.
  • Sisodiya SM; Department of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK; Chalfont Centre for Epilepsy (CCE), Chalfont St Peter, Bucks SL9 0RJ, UK.
Epilepsy Behav ; 115: 107602, 2021 02.
Article in English | MEDLINE | ID: covidwho-908849
ABSTRACT
In this cohort study, we aim to compare outcomes from coronavirus disease 2019 (COVID-19) in people with severe epilepsy and other co-morbidities living in long-term care facilities which all implemented early preventative measures, but different levels of surveillance. During 25-week observation period (16 March-6 September 2020), we included 404 residents (118 children), and 1643 caregivers. We compare strategies for infection prevention, control, and containment, and related outcomes, across four UK long-term care facilities. Strategies included early on-site enhancement of preventative and infection control measures, early identification and isolation of symptomatic cases, contact tracing, mass surveillance of asymptomatic cases and contacts. We measured infection rate among vulnerable people living in the facilities and their caregivers, with asymptomatic and symptomatic cases, including fatality rate. We report 38 individuals (17 residents) who tested severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive, with outbreaks amongst residents in two facilities. At Chalfont Centre for Epilepsy (CCE), 10/98 residents tested positive two symptomatic (one died), eight asymptomatic on weekly enhanced surveillance; 2/275 caregivers tested positive one symptomatic, one asymptomatic. At St Elizabeth's (STE), 7/146 residents tested positive four symptomatic (one died), one positive during hospital admission for symptoms unrelated to COVID-19, two asymptomatic on one-off testing of all 146 residents; 106/601 symptomatic caregivers were tested, 13 positive. In addition, during two cycles of systematically testing all asymptomatic carers, four tested positive. At The Meath (TM), 8/80 residents were symptomatic but none tested; 26/250 caregivers were tested, two positive. At Young Epilepsy (YE), 8/80 children were tested, all negative; 22/517 caregivers were tested, one positive. Infection outbreaks in long-term care facilities for vulnerable people with epilepsy can be quickly contained, but only if asymptomatic individuals are identified through enhanced surveillance at resident and caregiver level. We observed a low rate of morbidity and mortality, which confirmed that preventative measures with isolation of suspected and confirmed COVID-19 residents can reduce resident-to-resident and resident-to-caregiver transmission. Children and young adults appear to have lower infection rates. Even in people with epilepsy and multiple co-morbidities, we observed a high percentage of asymptomatic people suggesting that epilepsy-related factors (anti-seizure medications and seizures) do not necessarily lead to poor outcomes.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Residential Facilities / Infection Control / Long-Term Care / Epilepsy / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: Epilepsy Behav Journal subject: Behavioral Sciences / Neurology Year: 2021 Document Type: Article Affiliation country: J.yebeh.2020.107602

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Residential Facilities / Infection Control / Long-Term Care / Epilepsy / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: Epilepsy Behav Journal subject: Behavioral Sciences / Neurology Year: 2021 Document Type: Article Affiliation country: J.yebeh.2020.107602