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Evolution patterns of SARS-CoV-2: Snapshot on its genome variants.
Giovanetti, Marta; Benedetti, Francesca; Campisi, Giovanni; Ciccozzi, Alessandra; Fabris, Silvia; Ceccarelli, Giancarlo; Tambone, Vittoradolfo; Caruso, Arnaldo; Angeletti, Silvia; Zella, Davide; Ciccozzi, Massimo.
  • Giovanetti M; Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus, Rome, Italy.
  • Benedetti F; Institute of Human Virology, Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland Baltimore, USA.
  • Campisi G; Department of Molecular and Translational Medicine, Section of Microbiology, Universityof Brescia, Brescia, Italy.
  • Ciccozzi A; Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus, Rome, Italy.
  • Fabris S; Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus, Rome, Italy.
  • Ceccarelli G; Dipartimento di Salute Pubblica e Malattie Infettive, Policlinico Umberto I Università'Sapienza', Rome, Italy.
  • Tambone V; Anthropology, and Applied Ethics, Campus Bio-Medico University, Rome, Italy.
  • Caruso A; Department of Molecular and Translational Medicine, Section of Microbiology, Universityof Brescia, Brescia, Italy.
  • Angeletti S; Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy.
  • Zella D; Institute of Human Virology, Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland Baltimore, USA.
  • Ciccozzi M; Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus, Rome, Italy. Electronic address: M.ciccozzi@unicampus.it.
Biochem Biophys Res Commun ; 538: 88-91, 2021 01 29.
Article in English | MEDLINE | ID: covidwho-912050
ABSTRACT
An acute respiratory syndrome (COVID-19), caused by a novel coronavirus (SARS-CoV-2) with a high rate of morbidity and elevate mortality, has emerged as one of the most important threats to humankind in the last centuries. Rigorous determination of SARS-CoV-2 infectivity is very difficult owing to the continuous evolution of the virus, with its single nucleotide polymorphism (SNP) variants and many lineages. However, it is urgently necessary to study the virus in depth, to understand the mechanism of its pathogenicity and virulence, and to develop effective therapeutic strategies. The present contribution summarizes in a succinct way the current knowledge on the evolutionary and structural features of the virus, with the aim of clarifying its mutational pattern and its possible role in the ongoing pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Genome, Viral / Evolution, Molecular / SARS-CoV-2 / COVID-19 Type of study: Randomized controlled trials Topics: Variants Limits: Humans Language: English Journal: Biochem Biophys Res Commun Year: 2021 Document Type: Article Affiliation country: J.bbrc.2020.10.102

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Genome, Viral / Evolution, Molecular / SARS-CoV-2 / COVID-19 Type of study: Randomized controlled trials Topics: Variants Limits: Humans Language: English Journal: Biochem Biophys Res Commun Year: 2021 Document Type: Article Affiliation country: J.bbrc.2020.10.102