Comorbid diabetes and the risk of disease severity or death among 8807 COVID-19 patients in China: A meta-analysis.
Diabetes Res Clin Pract
; 166: 108346, 2020 Aug.
Article
in English
| MEDLINE | ID: covidwho-912147
ABSTRACT
AIMS:
Diabetes mellitus has been reported to be one of the most prevalent comorbidity in patients with Coronavirus Disease 2019 (COVID-19). We aimed to assess the association of comorbid diabetes with COVID-19 severity or mortality in China.METHODS:
We performed a systematic literature search from six electronic databases on diabetes and COVID-19. The outcome of interest was disease severity or mortality. Heterogeneity among the studies was assessed by the Cochran Q test and the I2 statistic. A random effects model was applied to calculate the pooled risk ratio (RR) with 95% confidence interval (CI).RESULTS:
Nine studies from different provinces/cities were identified according to the predefined inclusion and exclusion criteria. There were a total of 1070 patients with diabetes, out of the 8807 COVID-19 cases. The majority of the cases were derived from Hubei Province. A low degree of heterogeneity in the risk estimates was observed in the included studies. Meta-analysis showed that there was a significant association of preexisting diabetes with disease severity or death. The pooled RR was 2.96 (95% CI 2.31-3.79; p < 0.001). Sensitivity analysis demonstrated no significant changes in the pooled estimates.CONCLUSIONS:
Comorbid diabetes was associated with an increased risk of disease severity or death in Chinese COVID-19 patients.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Diabetes Complications
/
Diabetes Mellitus
/
Betacoronavirus
Type of study:
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Long Covid
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Diabetes Res Clin Pract
Journal subject:
Endocrinology
Year:
2020
Document Type:
Article
Affiliation country:
J.diabres.2020.108346
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