High-density lipoprotein cholesterol as a factor affecting virus clearance in covid-19 patients.
Respir Med
; 175: 106218, 2020 12.
Article
in English
| MEDLINE | ID: covidwho-912594
ABSTRACT
OBJECTIVE:
There were COVID-19 patients with SARS-COV-2 nucleic acid long-term positive. This article aims to understand the relevant factors that affect SARS-COV-2 clearance time.METHODS:
The clinical data of 115 COVID-19 patients with SARS-COV-2 nucleic acid positive time exceeding 14 days were collected retrospectively, and the relationship between clinical characteristics, chest CT scans, blood cells, biochemical indicators, and the time of viral nucleic acid turning negative were analyzed.RESULTS:
The time from symptom onsets to nucleic acid turning negative was (32.5 ± 8.7) days in this group of patients. The time of nucleic acid turning negative no fever group was longer than fever group, diabetes group was longer than no comorbidity group, elevated levels of ALT (alanine aminotransferase), or GLU (fasting blood glucose) group, decreased levels of ALB (albumin) group or HDLC (high-density lipoprotein cholesterol) group was longer than it's normal group separately (P < 0.05). Cox multivariate regression analysis showed that ALT [odds ratio (OR) 2.164 (95% CI 1.276-3.670), P = 0.004], GLU [OR 2.064 (95% CI 1.195-3.566), P = 0.009] and HDLC [OR 0.527 (95% CI 0.307-0.907), P = 0.021] were independent factors which affected the time of nucleic acid turning negative.CONCLUSIONS:
ALT, GLU and HDLC were independent factors that influenced the time of nucleic acid turning negative. Although diabetes or hyperglycemia is a known risk factor, HDLC is the first to be identified, clinicians should be aware of dyslipidemia in covid-19 patients.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
SARS-CoV-2
/
COVID-19
/
Cholesterol, HDL
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
English
Journal:
Respir Med
Year:
2020
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS