Risk factors for redetectable positivity in recovered COVID-19 children.
Pediatr Pulmonol
; 55(12): 3602-3609, 2020 12.
Article
in English
| MEDLINE | ID: covidwho-915178
ABSTRACT
OBJECTIVE:
To identify the risk factors for redetectable positivity (RP), and to provide a basis for prevention and control of coronavirus disease-2019 (COVID-19) in children.METHODS:
A retrospective study was performed on all pediatric patients diagnosed with COVID-19. RP was defined as the positive result of real-time reverse transcriptase polymerase chain reaction (RT-PCR) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after symptom resolution and discharge. Children were defined as being less than 18 years old.RESULTS:
Fourteen out of 38 (36.8%) pediatric patients exhibited RP. Compared with the non-RP group (n = 24), the RP group (n = 14) had more family cluster infections, relatively higher white blood cell (WBC) count and longer plasma prothrombin time (PT), while age and gender were insignificant. T lymphocyte subclassification was observed at five-time points the first test after admission, 2 weeks, and 1, 2, and 3 months after discharge. The RP group had a higher percentage and count of CD8+ T lymphocytes and lower CD4+/CD8+ ratio at 2 weeks, while a lower percentage and count of CD4+ T lymphocytes and lower CD4+/CD8+ ratio at 2 months. The positive rate of nasopharyngeal swabs by RT-PCR was higher during the onset, while that of anal swabs was higher during the recovery of COVID-19.CONCLUSIONS:
Family cluster infection, higher WBC count, and longer PT are the early risk factors for RP in recovered COVID-19 children. The dynamic changes in number and ratio of CD4+ and CD8+ T lymphocytes may be involved in prolonged SARS-CoV-2 clearance. Nasopharyngeal swabs sampling during the onset and anal swabs sampling during the recovery may improve the positivity rate of RT-PCR.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Anal Canal
/
Pneumonia, Viral
/
CD4-Positive T-Lymphocytes
/
Nasopharynx
/
Coronavirus Infections
/
CD8-Positive T-Lymphocytes
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Topics:
Long Covid
/
Vaccines
Language:
English
Journal:
Pediatr Pulmonol
Journal subject:
Pediatrics
Year:
2020
Document Type:
Article
Affiliation country:
Ppul.25116
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