Your browser doesn't support javascript.
COVID-19: Is there a role for immunonutrition in obese patient?
Di Renzo, Laura; Gualtieri, Paola; Pivari, Francesca; Soldati, Laura; Attinà, Alda; Leggeri, Claudia; Cinelli, Giulia; Tarsitano, Maria Grazia; Caparello, Giovanna; Carrano, Elena; Merra, Giuseppe; Pujia, Alberto Maria; Danieli, Roberta; De Lorenzo, Antonino.
  • Di Renzo L; Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy.
  • Gualtieri P; Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy.
  • Pivari F; Department of Health Sciences, University of Milan, Via A. Di Rudinì 8, 20142, Milan, Italy. francesca.pivari@unimi.it.
  • Soldati L; Department of Health Sciences, University of Milan, Via A. Di Rudinì 8, 20142, Milan, Italy.
  • Attinà A; School of Specialization in Food Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy.
  • Leggeri C; School of Specialization in Food Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy.
  • Cinelli G; School of Specialization in Food Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy.
  • Tarsitano MG; Predictive and Preventive Medicine Research Unit, "Bambino Gesù" Children Hospital IRCCS, 00165, Rome, Italy.
  • Caparello G; Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
  • Carrano E; School of Specialization in Food Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy.
  • Merra G; School of Specialization in Food Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy.
  • Pujia AM; Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy.
  • Danieli R; Department of Surgery, University of Tor Vergata, Via Montpellier 1, 00133, Rome, Italy.
  • De Lorenzo A; Telematic University of San Raffaele Rome, 00166, Rome, Italy.
J Transl Med ; 18(1): 415, 2020 11 07.
Article in English | MEDLINE | ID: covidwho-916349
ABSTRACT
On December 12, 2019 a new coronavirus (SARS-CoV-2) emerged in Wuhan, China, triggering a pandemic of severe acute respiratory syndrome in humans (COVID-19). Today, the scientific community is investing all the resources available to find any therapy and prevention strategies to defeat COVID-19. In this context, immunonutrition can play a pivotal role in improving immune responses against viral infections. Immunonutrition has been based on the concept that malnutrition impairs immune function. Therefore, immunonutrition involves feeding enriched with various pharmaconutrients (Omega 3 Fatty Acids, Vitamin C, Arginine, Glutamine, Selenium, Zinc, Vitamin, E and Vitamin D) to modulate inflammatory responses, acquired immune response and to improve patient outcomes. In literature, significant evidences indicate that obesity, a malnutrition state, negatively impacts on immune system functionality and on host defense, impairing protection from infections. Immunonutrients can promote patient recovery by inhibiting inflammatory responses and regulating immune function. Immune system dysfunction is considered to increase the risk of viral infections, such as SARS-CoV-2, and was observed in different pathological situations. Obese patients develop severe COVID-19 sequelae, due to the high concentrations of TNF-α, MCP-1 and IL-6 produced in the meantime by visceral and subcutaneous adipose tissue and by innate immunity. Moreover, leptin, released by adipose tissue, helps to increase inflammatory milieu with a dysregulation of the immune response. Additionally, gut microbiota plays a crucial role in the maturation, development and functions of both innate and adaptive immune system, as well as contributing to develop obese phenotype. The gut microbiota has been shown to affect lung health through a vital crosstalk between gut microbiota and lungs, called the "gut-lung axis". This axis communicates through a bi-directional pathway in which endotoxins, or microbial metabolites, may affect the lung through the blood and when inflammation occurs in the lung, this in turn can affect the gut microbiota. Therefore, the modulation of gut microbiota in obese COVID-19 patients can play a key role in immunonutrition therapeutic strategy. This umbrella review seeks to answer the question of whether a nutritional approach can be used to enhance the immune system's response to obesity in obese patients affected by COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Immune System / Nutritional Physiological Phenomena / Obesity Type of study: Prognostic study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: J Transl Med Year: 2020 Document Type: Article Affiliation country: S12967-020-02594-4

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Immune System / Nutritional Physiological Phenomena / Obesity Type of study: Prognostic study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: J Transl Med Year: 2020 Document Type: Article Affiliation country: S12967-020-02594-4