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Risk of pre-term births and major birth defects resulting from paternal intake of COVID-19 medications prior to conception.
Rizzi, Silvia; Wensink, Maarten J; Lindahl-Jacobsen, Rune; Tian, Lu; Lu, Ying; Eisenberg, Michael L.
  • Rizzi S; Department of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, Denmark.
  • Wensink MJ; Interdisciplinary Centre on Population Dynamics, University of Southern Denmark, Odense, Denmark.
  • Lindahl-Jacobsen R; Department of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, Denmark.
  • Tian L; Interdisciplinary Centre on Population Dynamics, University of Southern Denmark, Odense, Denmark.
  • Lu Y; Department of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, Denmark.
  • Eisenberg ML; Interdisciplinary Centre on Population Dynamics, University of Southern Denmark, Odense, Denmark.
BMC Res Notes ; 13(1): 509, 2020 Nov 07.
Article in English | MEDLINE | ID: covidwho-916351
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ABSTRACT

OBJECTIVE:

With the ongoing COVID-19 pandemic, large numbers of people will receive one of the several medications proposed to treat COVID-19, including patients of reproductive age. Given that some medications have shown adverse effects on sperm quality, there might be a transgenerational concern. We aim at examining the association between drugs proposed to treat COVID-19 when taken by the father around conception and any pre-term birth or major birth defects in offspring in a nation-wide cohort study using Danish registry data. Offspring whose father filled at least one prescription of the following medications in the 3 months preceding conception were considered exposed chloroquine, hydroxychloroquine, losartan, azithromycin, naproxen, dexamethasone and prednisone.

RESULTS:

For azithromycin and naproxen, large numbers of offspring were exposed (> 1800 offspring), and we found no association with adverse birth outcomes. For chloroquine, losartan and dexamethasone, exposure was intermediate (~ 900 offspring), and there was no statistically significant association with birth defects. For hydroxychloroquine and prednisone, exposure was limited (< 300 offspring). Our evidence suggests that azithromycin and naproxen are safe with respect to pre-term birth and birth defects. For the other drugs investigated larger exposures are needed for conclusive statements.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Abnormalities, Drug-Induced / Coronavirus Infections / Paternal Exposure / Premature Birth Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Female / Humans / Male Country/Region as subject: Europa Language: English Journal: BMC Res Notes Year: 2020 Document Type: Article Affiliation country: S13104-020-05358-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Abnormalities, Drug-Induced / Coronavirus Infections / Paternal Exposure / Premature Birth Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Female / Humans / Male Country/Region as subject: Europa Language: English Journal: BMC Res Notes Year: 2020 Document Type: Article Affiliation country: S13104-020-05358-x