Signaling by cGAS-STING in Neurodegeneration, Neuroinflammation, and Aging.
Trends Neurosci
; 44(2): 83-96, 2021 02.
Article
in English
| MEDLINE | ID: covidwho-916894
ABSTRACT
Recognition of foreign or misplaced nucleic acids is one of the principal modes by which the immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is relayed via the cGAS-STING pathway this involves the activation of cyclic GMP-AMP (cGMP-AMP) synthase (cGAS) and generation of the cyclic dinucleotide cGAMP, followed by the induction of stimulator of interferon genes (STING). The cGAS-STING pathway responds to viral, bacterial, and self-DNA. Whereas it generally mediates immune surveillance and is often neuroprotective, excessive engagement of the system can be deleterious. This is relevant in aging and age-related neurological diseases, where neuroinflammation contributes to disease progression. This review focuses on cGAS-STING signaling in aging, neurodegeneration, and neuroinflammation, and on therapeutic implications.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Neurodegenerative Diseases
/
Membrane Proteins
/
Nucleotidyltransferases
Limits:
Humans
Language:
English
Journal:
Trends Neurosci
Year:
2021
Document Type:
Article
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