Your browser doesn't support javascript.
COVID-19, thromboembolic risk, and Virchow's triad: Lesson from the past.
Mehta, Jawahar L; Calcaterra, Giuseppe; Bassareo, Pier P.
  • Mehta JL; Division of Cardiology, University of Arkansas for Medical Sciences and the VA Medical Canter, Little Rock, Arkansas, USA.
  • Calcaterra G; Postgraduate medical School, University of Palermo, Palermo, Italy.
  • Bassareo PP; University College of Dublin, Mater Misericordiae University Hospital, Dublin, Republic of Ireland.
Clin Cardiol ; 43(12): 1362-1367, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-917084
ABSTRACT
COronavirus Infectious Disease which started in 2019 (COVID-19) usually presents with the signs and symptoms of pneumonia. However, a growing number of recent reports highlight the fact that the infection may be by far more than only a respiratory disease. There is evidence of an increased thromboembolic risk in COVID-19 patients, with a variety of manifestations in terms of ischemic stroke, deep vein thrombosis, acute pulmonary embolism, acute myocardial infarction, systemic arterial embolism, and placental thrombosis. The German physician Rudolph Virchow, about two centuries ago, described three pivotal factors contributing together to thromboembolic risk endothelial injury, hypercoagulability, and blood stasis. COVID-19-associated hypercoagulability is unique and distinctive, and has its own features involving the immune system. Many of the drugs proposed and currently undergoing evaluation for the treatment of COVID-19 have one or more of the Virchow's triad elements as a target. The three factors outlined by Virchow are still able to explain the venous and arterial hypercoagulable state in the dramatic COVID-19 setting. Nowadays, we have decidedly more sophisticated diagnostic tools than Virchow had, but many of the challenges that we are facing are the same as Virchow faced in the 19th century.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Thromboembolism / Coronavirus Infections / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Clin Cardiol Year: 2020 Document Type: Article Affiliation country: Clc.23460

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Thromboembolism / Coronavirus Infections / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Clin Cardiol Year: 2020 Document Type: Article Affiliation country: Clc.23460