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COVID-19 pandemic effect on early pregnancy: are miscarriage rates altered, in asymptomatic women?
Rotshenker-Olshinka, Keren; Volodarsky-Perel, Alexander; Steiner, Naama; Rubenfeld, Eryn; Dahan, Michael H.
  • Rotshenker-Olshinka K; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, McGill University, Montréal, QC, H3A 0G4, Canada. kerenlogic@gmail.com.
  • Volodarsky-Perel A; Department of Obstetrics and Gynecology Shaare Zedek Medical Center, Affiliated with the Hebrew University, 9103102, Jerusalem, Israel. kerenlogic@gmail.com.
  • Steiner N; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, McGill University, Montréal, QC, H3A 0G4, Canada.
  • Rubenfeld E; Lady Davis Research Institute, Jewish General Hospital, Montréal, QC, Canada.
  • Dahan MH; Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Arch Gynecol Obstet ; 303(3): 839-845, 2021 03.
Article in English | MEDLINE | ID: covidwho-917115
ABSTRACT

PURPOSE:

To evaluate the effect of the COVID-19 pandemic state on early, first-trimester pregnancies.

METHODS:

A retrospective cohort study conducted at a university-affiliated fertility center in Montreal, Quebec, since the COVID-19 shut down, March 13 until May 6, 2020. Included all women who came for a first-trimester viability scan during the study period (Study group) and between March 1, 2019 and May 17, 2019, approximately one year prior (Control). The study population denied symptoms of COVID-19. We reviewed all first trimester scans. Early first-trimester pregnancy outcomes (Viable pregnancy, arrested pregnancy including biochemical pregnancy loss and miscarriage, and ectopic pregnancy) were measured as total number and percentage. A multivariate analysis was performed to control for other potentially significant variables, as was a power analysis supporting sample size.

RESULTS:

113 women came for a first-trimester viability scan in the study period, and 172 in the control period (5-11 weeks gestational age), mean maternal age 36.5 ± 4.5 and 37.2 ± 5.4 years (p = 0.28). Viable clinical pregnancy rate was not different between the two groups (76.1 vs. 80.2% in the pandemic and pre-pandemic groups p = 0.41). No significant difference was seen in the total number of arrested pregnancies (defined as the sum of biochemical, 1st trimester miscarriages, and blighted ova) (22.1 vs. 16.9% p = 0.32), or in each type of miscarriage.

CONCLUSION:

The COVID-19 pandemic environment does not seem to affect early first-trimester miscarriage rates in asymptomatic patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Abortion, Spontaneous / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Female / Humans / Pregnancy Country/Region as subject: North America Language: English Journal: Arch Gynecol Obstet Journal subject: Gynecology / Obstetrics Year: 2021 Document Type: Article Affiliation country: S00404-020-05848-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Abortion, Spontaneous / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Female / Humans / Pregnancy Country/Region as subject: North America Language: English Journal: Arch Gynecol Obstet Journal subject: Gynecology / Obstetrics Year: 2021 Document Type: Article Affiliation country: S00404-020-05848-0