When hematologic malignancies meet COVID-19 in the United States: Infections, death and disparities.
Blood Rev
; 47: 100775, 2021 05.
Article
in English
| MEDLINE | ID: covidwho-917231
ABSTRACT
Scientific data is limited on the risks, adverse outcomes and racial disparities for COVID-19 illness in individuals with hematologic malignancies in the United States. To fill this void, we screened and analyzed a nation-wide database of patient electronic health records (EHRs) of 73 million patients in the US (up to September 1st) for COVID-19 and eight major types of hematologic malignancies. Patients with hematologic malignancies had increased odds of COVID-19 infection compared with patients without hematologic malignancies for both all-time diagnosis (malignancy diagnosed in the past year or prior) (adjusted Odds ratio or AOR 2.27 [2.17-2.36], p < 0.001) and recent diagnosis (malignancy diagnosed in the past year) (AOR11.91 [11.31-12.53], p < 0.001), with strongest effect for recently diagnosed acute lymphoid leukemia (AOR 31.03 [25.87-37.27], p < 0.001), essential thrombocythemia (AOR 20.65 [19.10-22.32], p < 0.001), acute myeloid leukemia (AOR 18.94 [15.79-22.73], p < 0.001), multiple myeloma (AOR 14.21 [12.72-15.89], p < 0.001). Among patients with hematologic malignancies, African Americans had higher odds of COVID-19 infection than Caucasians with largest racial disparity for multiple myeloma (AOR 4.23 [3.21-5.56], p < 0.001). Patients with recently diagnosed hematologic malignancies had worse outcomes (hospitalization 51.9%, death 14.8%) than COVID-19 patients without hematologic malignancies (hospitalization 23.5%, death 5.1%) (p < 0.001) and hematologic malignancy patients without COVID-19 (hospitalization 15.0%, death 4.1%) (p < 0.001).
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Hematologic Neoplasms
/
COVID-19
Type of study:
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
/
Young adult
Country/Region as subject:
North America
Language:
English
Journal:
Blood Rev
Journal subject:
Hematology
Year:
2021
Document Type:
Article
Affiliation country:
J.blre.2020.100775
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