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From angiotensin-converting enzyme 2 disruption to thromboinflammatory microvascular disease: A paradigm drawn from COVID-19.
Vinci, R; Pedicino, D; Andreotti, F; Russo, G; D'Aiello, A; De Cristofaro, R; Crea, F; Liuzzo, G.
  • Vinci R; Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy.
  • Pedicino D; Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Andreotti F; Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy; Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. Electronic address: felicita.andreotti@unicatt.it.
  • Russo G; Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy.
  • D'Aiello A; Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy.
  • De Cristofaro R; Haemorrhagic and Thrombotic Diseases, Fondazione Policlinico Universitario "A. Gemelli", IRCCS, Rome, Italy; Institute of Internal Medicine and Geriatrics, Catholic University School of Medicine, Rome, Italy.
  • Crea F; Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy; Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Liuzzo G; Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy; Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Int J Cardiol ; 326: 243-247, 2021 03 01.
Article in English | MEDLINE | ID: covidwho-917306
ABSTRACT
We concisely review clinical, autopsy, experimental and molecular data of 2019 coronavirus disease (COVID-19). Angiotensin-converting enzyme 2 disruption and thromboinflammatory microangiopathy emerge as distinctive features. Briefly, entry of the virus into microvessels can profoundly disrupt the local renin-angiotensin system, cause endothelial injury, activate the complement cascade and induce powerful thromboinflammatory reactions, involving, in particular, von Willebrand factor, that, if widespread, may lead to microvascular plugging, ischemia and, ultimately, organ failure. We believe the current COVID-19 data consolidate a widely unrecognised paradigm of potentially fatal thromboinflammatory microvascular disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Inflammation Mediators / Microvessels / Angiotensin-Converting Enzyme 2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Reviews Limits: Humans Language: English Journal: Int J Cardiol Year: 2021 Document Type: Article Affiliation country: J.ijcard.2020.11.016

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Inflammation Mediators / Microvessels / Angiotensin-Converting Enzyme 2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Reviews Limits: Humans Language: English Journal: Int J Cardiol Year: 2021 Document Type: Article Affiliation country: J.ijcard.2020.11.016