PolarProtDb: A Database of Transmembrane and Secreted Proteins showing Apical-Basal Polarity.
J Mol Biol
; 433(11): 166705, 2021 05 28.
Article
in English
| MEDLINE | ID: covidwho-917347
ABSTRACT
Most cells in multicellular organisms are somehow asymmetric, polarized maintaining separate membrane domains. Typical examples are the epithelial cells (apical-basal polarization), neurons (dendritic-axonal domains), or migratory cells (with a leading and a trailing edge). Here we present the most comprehensive database containing experimentally verified mammalian proteins that display polarized sorting or secretion, focusing on epithelial polarity. In addition to the source cells or tissues, homology-based inferences and transmembrane topology (if applicable) are all provided. PolarProtDb also offers a detailed interface displaying all information that may be relevant for trafficking including post-translational modifications (glycosylations and phosphorylations), known or predicted short linear motifs conserved across orthologs, as well as potential interaction partners. Data on polarized sorting has so far been scattered across myriads of publications, hence difficult to access. This information can help researchers in several areas, such as scanning for potential entry points of viral agents like COVID-19. PolarProtDb shall be a useful resource to design future experiments as well as for comparative analyses. The database is available at http//polarprotdb.enzim.hu.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Databases, Factual
/
Epithelial Cells
/
Membrane Proteins
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
J Mol Biol
Year:
2021
Document Type:
Article
Affiliation country:
J.jmb.2020.11.004
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