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Food-derived antioxidants and COVID-19.
Lammi, Carmen; Arnoldi, Anna.
  • Lammi C; Department of Pharmaceutical Science, University of Milan, Milan, Italy.
  • Arnoldi A; Department of Pharmaceutical Science, University of Milan, Milan, Italy.
J Food Biochem ; 45(1): e13557, 2021 01.
Article in English | MEDLINE | ID: covidwho-917749
Semantic information from SemMedBD (by NLM)
1. Organ LOCATION_OF MULTISYSTEM DISORDER
Subject
Organ
Predicate
LOCATION_OF
Object
MULTISYSTEM DISORDER
2. MULTISYSTEM DISORDER COEXISTS_WITH Oxidative Stress
Subject
MULTISYSTEM DISORDER
Predicate
COEXISTS_WITH
Object
Oxidative Stress
3. MULTISYSTEM DISORDER COEXISTS_WITH Inflammatory Response
Subject
MULTISYSTEM DISORDER
Predicate
COEXISTS_WITH
Object
Inflammatory Response
4. Prophylactic treatment USES Dietary Supplements
Subject
Prophylactic treatment
Predicate
USES
Object
Dietary Supplements
5. Prophylactic treatment USES Nutraceuticals
Subject
Prophylactic treatment
Predicate
USES
Object
Nutraceuticals
6. Therapeutic procedure TREATS COVID-19
Subject
Therapeutic procedure
Predicate
TREATS
Object
COVID-19
7. Antioxidants AFFECTS Chronic disease
Subject
Antioxidants
Predicate
AFFECTS
Object
Chronic disease
8. COVID-19 COEXISTS_WITH Chronic disease
Subject
COVID-19
Predicate
COEXISTS_WITH
Object
Chronic disease
9. Antioxidants PREVENTS Oxidative Stress
Subject
Antioxidants
Predicate
PREVENTS
Object
Oxidative Stress
10. Metal Chelating Agents PREVENTS Inflammation
Subject
Metal Chelating Agents
Predicate
PREVENTS
Object
Inflammation
11. Metal Chelating Agents PREVENTS Oxidative Stress
Subject
Metal Chelating Agents
Predicate
PREVENTS
Object
Oxidative Stress
12. Antioxidants PREVENTS Inflammation
Subject
Antioxidants
Predicate
PREVENTS
Object
Inflammation
13. Inflammation COEXISTS_WITH COVID-19
Subject
Inflammation
Predicate
COEXISTS_WITH
Object
COVID-19
14. Oxidative Stress COEXISTS_WITH COVID-19
Subject
Oxidative Stress
Predicate
COEXISTS_WITH
Object
COVID-19
15. Organ LOCATION_OF MULTISYSTEM DISORDER
Subject
Organ
Predicate
LOCATION_OF
Object
MULTISYSTEM DISORDER
16. MULTISYSTEM DISORDER COEXISTS_WITH Oxidative Stress
Subject
MULTISYSTEM DISORDER
Predicate
COEXISTS_WITH
Object
Oxidative Stress
17. MULTISYSTEM DISORDER COEXISTS_WITH Inflammatory Response
Subject
MULTISYSTEM DISORDER
Predicate
COEXISTS_WITH
Object
Inflammatory Response
18. Prophylactic treatment USES Dietary Supplements
Subject
Prophylactic treatment
Predicate
USES
Object
Dietary Supplements
19. Prophylactic treatment USES Nutraceuticals
Subject
Prophylactic treatment
Predicate
USES
Object
Nutraceuticals
20. Therapeutic procedure TREATS COVID-19
Subject
Therapeutic procedure
Predicate
TREATS
Object
COVID-19
21. Antioxidants AFFECTS Chronic disease
Subject
Antioxidants
Predicate
AFFECTS
Object
Chronic disease
22. COVID-19 COEXISTS_WITH Chronic disease
Subject
COVID-19
Predicate
COEXISTS_WITH
Object
Chronic disease
23. Antioxidants PREVENTS Oxidative Stress
Subject
Antioxidants
Predicate
PREVENTS
Object
Oxidative Stress
24. Metal Chelating Agents PREVENTS Inflammation
Subject
Metal Chelating Agents
Predicate
PREVENTS
Object
Inflammation
25. Metal Chelating Agents PREVENTS Oxidative Stress
Subject
Metal Chelating Agents
Predicate
PREVENTS
Object
Oxidative Stress
26. Antioxidants PREVENTS Inflammation
Subject
Antioxidants
Predicate
PREVENTS
Object
Inflammation
27. Inflammation COEXISTS_WITH COVID-19
Subject
Inflammation
Predicate
COEXISTS_WITH
Object
COVID-19
28. Oxidative Stress COEXISTS_WITH COVID-19
Subject
Oxidative Stress
Predicate
COEXISTS_WITH
Object
COVID-19
ABSTRACT
SARS-CoV-2 (previously 2019-nCoV), the pathogenic agent of COVID-19 disease, started to expand from Wuhan, China, on December 2019 and in 2 months, it spread worldwide giving origin to a pandemic. COVID-19 has a stronger transmission capacity by inhalation of infectious aerosols and after an incubation time of 3-14 days, it may be responsible for diseases ranging from the asymptomatic to fatal consequences. COVID-19 has emerged as a multifaceted, multisystem, multi-organ disorder, which produces its pathogenic effects through a quite ubiquitous target at the level of multiple organs and in which oxidative stress and inflammatory process play relevant roles. Thus, besides the development of a pharmacological therapy, in the field of alternative and coadjutant therapeutic, the use of dietary supplements or nutraceuticals for the prevention or treatment of SARS-CoV-2 infection may be a useful strategy. Herein, we specifically comment on some literature evidences, which link the food-derived antioxidants and metal-chelating agents with treatment and prevention of oxidative stress and inflammation that play a key role in the progression of COVID-19. PRACTICAL APPLICATIONS Oxidative stress and inflammation are key factors increasing COVID-19 severity especially in the presence of chronic diseases associated with the antioxidant system fragility. These evidences support the recommendation of antioxidants supplementation as useful strategies against COVID-19. In light with these observations, herein, a comment which describes the major antioxidants and metal-chelating agents from food sources that might be useful for the treatment and prevention of oxidative stress and inflammation during COVID-19.
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Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Plant Extracts / COVID-19 / Antioxidants Type of study: Clinical Practice Guide Limits: Humans Language: English Journal: J Food Biochem Year: 2021 Document Type: Article Affiliation country: Jfbc.13557

Full text: Available Collection: International databases Database: MEDLINE Main subject: Plant Extracts / COVID-19 / Antioxidants Type of study: Clinical Practice Guide Limits: Humans Language: English Journal: J Food Biochem Year: 2021 Document Type: Article Affiliation country: Jfbc.13557