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Isolated Lung Perfusion in the Management of Acute Respiratory Distress Syndrome.
Haywood, Nathan; Byler, Matthew R; Zhang, Aimee; Roeser, Mark E; Kron, Irving L; Laubach, Victor E.
  • Haywood N; Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22902, USA.
  • Byler MR; Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22902, USA.
  • Zhang A; Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22902, USA.
  • Roeser ME; Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22902, USA.
  • Kron IL; Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22902, USA.
  • Laubach VE; Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22902, USA.
Int J Mol Sci ; 21(18)2020 Sep 17.
Article in English | MEDLINE | ID: covidwho-918204
ABSTRACT
Acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality, and current management has a dramatic impact on healthcare resource utilization. While our understanding of this disease has improved, the majority of treatment strategies remain supportive in nature and are associated with continued poor outcomes. There is a dramatic need for the development and breakthrough of new methods for the treatment of ARDS. Isolated machine lung perfusion is a promising surgical platform that has been associated with the rehabilitation of injured lungs and the induction of molecular and cellular changes in the lung, including upregulation of anti-inflammatory and regenerative pathways. Initially implemented in an ex vivo fashion to evaluate marginal donor lungs prior to transplantation, recent investigations of isolated lung perfusion have shifted in vivo and are focused on the management of ARDS. This review presents current tenants of ARDS management and isolated lung perfusion, with a focus on how ex vivo lung perfusion (EVLP) has paved the way for current investigations utilizing in vivo lung perfusion (IVLP) in the treatment of severe ARDS.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Perfusion / Respiratory Distress Syndrome / Lung Injury / Inflammation Type of study: Experimental Studies / Prognostic study Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: Ijms21186820

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Perfusion / Respiratory Distress Syndrome / Lung Injury / Inflammation Type of study: Experimental Studies / Prognostic study Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: Ijms21186820