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Seroprevalence of SARS-CoV-2 antibodies in children: a prospective multicentre cohort study.
Waterfield, Thomas; Watson, Chris; Moore, Rebecca; Ferris, Kathryn; Tonry, Claire; Watt, Alison; McGinn, Claire; Foster, Steven; Evans, Jennifer; Lyttle, Mark David; Ahmad, Shazaad; Ladhani, Shamez; Corr, Michael; McFetridge, Lisa; Mitchell, Hannah; Brown, Kevin; Amirthalingam, Gayatri; Maney, Julie-Ann; Christie, Sharon.
  • Waterfield T; Queen's University Belfast Wellcome-Wolfson Institute for Experimental Medicine, Belfast, UK thomas.waterfield@googlemail.com.
  • Watson C; Emergency Department, Children's Health Ireland at Temple Street, Dublin D01 YC67, Ireland.
  • Moore R; Queen's University Belfast Wellcome-Wolfson Institute for Experimental Medicine, Belfast, UK.
  • Ferris K; General Paediatrics, Royal Belfast Hospital for Sick Children, Belfast, UK.
  • Tonry C; Belfast Health and Social Care Trust, Belfast, UK.
  • Watt A; Queen's University Belfast Wellcome-Wolfson Institute for Experimental Medicine, Belfast, UK.
  • McGinn C; Regional Virus Laboratory, Belfast Health and Social Care Trust, Belfast, UK.
  • Foster S; General Paediatrics, Royal Belfast Hospital for Sick Children, Belfast, UK.
  • Evans J; Emergency Department, Royal Hospital for Children, Glasgow, UK.
  • Lyttle MD; Cardiff and Vale University Health Board, Cardiff, UK.
  • Ahmad S; Emergency Department, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
  • Ladhani S; Health and Applied Sciences, University of the West of England, Bristol, UK.
  • Corr M; Department of Virology, Manchester Medical Microbiology Partnership, Manchester University NHS Foundation Trust, Manchester, Greater Manchester, UK.
  • McFetridge L; Manchester Academic Health Science Centre, Manchester, UK.
  • Mitchell H; Immunisation and Countermeasures Division, Public Health England, London, UK.
  • Brown K; Belfast Health and Social Care Trust, Belfast, UK.
  • Amirthalingam G; Mathematical Sciences Research Centre, Queen's University Belfast, Belfast, UK.
  • Maney JA; Mathematical Sciences Research Centre, Queen's University Belfast, Belfast, UK.
  • Christie S; Virus Reference Department, Public Health England, Colindale, UK.
Arch Dis Child ; 106(7): 680-686, 2021 07.
Article in English | MEDLINE | ID: covidwho-919185
Preprint
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ABSTRACT

BACKGROUND:

Studies based on molecular testing of oral/nasal swabs underestimate SARS-CoV-2 infection due to issues with test sensitivity, test timing and selection bias. The objective of this study was to report the presence of SARS-CoV-2 antibodies, consistent with previous infection.

DESIGN:

This multicentre observational cohort study, conducted between 16 April to 3 July 2020 at 5 UK sites, recruited children of healthcare workers, aged 2-15 years. Participants provided blood samples for SARS-CoV-2 antibody testing and data were gathered regarding unwell contacts and symptoms.

RESULTS:

1007 participants were enrolled, and 992 were included in the final analysis. The median age of participants was 10·1 years. There were 68 (6.9%) participants with positive SARS-CoV-2 antibody tests indicative of previous SARS-CoV-2 infection. Of these, 34/68 (50%) reported no symptoms prior to testing. The presence of antibodies and the mean antibody titre was not influenced by age. Following multivariable analysis four independent variables were identified as significantly associated with SARS-CoV-2 seropositivity known infected household contact OR=10.9 (95% CI 6.1 to 19.6); fatigue OR=16.8 (95% CI 5.5 to 51.9); gastrointestinal symptoms OR=6.6 (95% CI 3.0 to 13.8); and changes in sense of smell or taste OR=10.0 (95% CI 2.4 to 11.4).

DISCUSSION:

Children demonstrated similar antibody titres in response to SARS-CoV-2 irrespective of age. Fatigue, gastrointestinal symptoms and changes in sense of smell or taste were the symptoms most strongly associated with SARS-CoV-2 antibody positivity. TRIAL REGISTRATION NUMBER NCT0434740.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gastrointestinal Diseases / SARS-CoV-2 / COVID-19 / Olfaction Disorders / Antibodies, Viral Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Child / Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Arch Dis Child Year: 2021 Document Type: Article Affiliation country: Archdischild-2020-320558

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gastrointestinal Diseases / SARS-CoV-2 / COVID-19 / Olfaction Disorders / Antibodies, Viral Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Child / Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Arch Dis Child Year: 2021 Document Type: Article Affiliation country: Archdischild-2020-320558