The nucleocapsid protein of zoonotic betacoronaviruses is an attractive target for antiviral drug discovery.
Life Sci
; 282: 118754, 2021 Oct 01.
Article
in English
| MEDLINE | ID: covidwho-919594
ABSTRACT
Betacoronaviruses are in one genera of coronaviruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome-related coronavirus (MERS-CoV), etc. These viruses threaten public health and cause dramatic economic losses. The nucleocapsid (N) protein is a structural protein of betacoronaviruses with multiple functions such as forming viral capsids with viral RNA, interacting with viral membrane protein to form the virus core with RNA, binding to several cellular kinases for signal transductions, etc. In this review, we highlighted the potential of the N protein as a suitable antiviral target from different perspectives, including structure, functions, and antiviral strategies for combatting betacoronaviruses.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Coronavirus Infections
/
Drug Discovery
/
Betacoronavirus
/
Coronavirus Nucleocapsid Proteins
Limits:
Animals
/
Humans
Language:
English
Journal:
Life Sci
Year:
2021
Document Type:
Article
Affiliation country:
J.lfs.2020.118754
Similar
MEDLINE
...
LILACS
LIS