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Oxygen-ozone (O2-O3) immunoceutical therapy for patients with COVID-19. Preliminary evidence reported.
Franzini, Marianno; Valdenassi, Luigi; Ricevuti, Giovanni; Chirumbolo, Salvatore; Depfenhart, Markus; Bertossi, Dario; Tirelli, Umberto.
  • Franzini M; SIOOT, High School in Oxygen Ozone Therapy, University of Pavia, Italy; SIOOT INTERNATIONAL, Communian Clinic, Gorle Bergamo, Italy.
  • Valdenassi L; SIOOT, High School in Oxygen Ozone Therapy, University of Pavia, Italy; SIOOT INTERNATIONAL, Communian Clinic, Gorle Bergamo, Italy.
  • Ricevuti G; Department of Drug Science, University of Pavia, Italy.
  • Chirumbolo S; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy. Electronic address: salvatore.chirumbolo@univr.it.
  • Depfenhart M; Venlo University B.V., Venlo, Netherlands.
  • Bertossi D; Department of Surgery, Dentistry, Paediatrics and Gynaecology Unit of Maxillo-Facial Surgery, University of Verona, Verona, Italy.
  • Tirelli U; SIOOT INTERNATIONAL, Communian Clinic, Gorle Bergamo, Italy; Department of Drug Science, University of Pavia, Italy.
Int Immunopharmacol ; 88: 106879, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-919641
Semantic information from SemMedBD (by NLM)
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COVID-19
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Patients
2. intensive care unit LOCATION_OF Experimental Design
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intensive care unit
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3. COVID-19 PROCESS_OF geriatric patients
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COVID-19
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4. Syndrome PROCESS_OF geriatric patients
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8. COVID-19 PROCESS_OF geriatric patients
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ABSTRACT

OBJECTIVE:

This study evaluated the potential efficacy of a novel approach to treat COVID-19 patients, using an oxygen-ozone (O2-O3) mixture, via a process called Oxygen-Ozone- Immunoceutical Therapy. The methodology met the criteria of a novel, promising approach to treat successfully elderly COVID-19 patients, particularly when hospitalized in intensive care units (ICUs) Experimental

design:

We investigated the therapeutic effect of 4 cycles of O2-O3 in 50 hospitalized COVID-19 subjects suffering from acute respiratory disease syndrome (ARDS), aged more than 60 years, all males and undergoing non invasive mechanical ventilation in ICUs.

RESULTS:

Following O2-O3 treatment a significant improvement in inflammation and oxygenation indexes occurred rapidly and within the first 9 days after the treatment, despite the expected 14-20 days. A significant reduction of inflammatory and thromboembolic markers (CRP, IL-6, D-dimer) was observed. Furthermore, amelioration in the major respiratory indexes, such as respiratory and gas exchange markers (SatO2%, PaO2/FiO2 ratio), was reported.

CONCLUSION:

Our results show that O2-O3 treatment would be a promising therapy for COVID-19 patients. It leads patients to a fast recovery from ARDS via the improvement of major respiratory indexes and blood gas parameters, following a relatively short time of dispensed forced ventilation (about one to two weeks). This study may encourage the scientific community to further investigate and evaluate the proposed method for the treatment of COVID-19 patients.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Oxygen / Ozone / Pneumonia, Viral / Respiratory Distress Syndrome / Coronavirus Infections / Immunotherapy Subject: Oxygen / Ozone / Pneumonia, Viral / Respiratory Distress Syndrome / Coronavirus Infections / Immunotherapy Type of study: Evidence synthesis Language: English Journal: Int Immunopharmacol Clinical aspect: Etiology Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Oxygen / Ozone / Pneumonia, Viral / Respiratory Distress Syndrome / Coronavirus Infections / Immunotherapy Subject: Oxygen / Ozone / Pneumonia, Viral / Respiratory Distress Syndrome / Coronavirus Infections / Immunotherapy Type of study: Evidence synthesis Language: English Journal: Int Immunopharmacol Clinical aspect: Etiology Year: 2020
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