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Tocilizumab-induced cytomegalovirus colitis in a patient with COVID-19.
Khatib, Mohamad Y; Shaik, Karimulla S; Ahmed, Amna A; Alwraidat, Mohammad A; Mohamed, Ahmed S; Abou Kamar, Mohamad R; Sharaf Eldean, Mouhammad Z; Aldaraiseh, Bashar K; Nashwan, Abdulqadir J.
  • Khatib MY; Critical Care Unit Hazm Mebaireek General Hospital (HMGH) Hamad Medical Corporation (HMC) Doha Qatar.
  • Shaik KS; Critical Care Unit Hazm Mebaireek General Hospital (HMGH) Hamad Medical Corporation (HMC) Doha Qatar.
  • Ahmed AA; Critical Care Unit Hazm Mebaireek General Hospital (HMGH) Hamad Medical Corporation (HMC) Doha Qatar.
  • Alwraidat MA; Critical Care Unit Hazm Mebaireek General Hospital (HMGH) Hamad Medical Corporation (HMC) Doha Qatar.
  • Mohamed AS; Critical Care Unit Hazm Mebaireek General Hospital (HMGH) Hamad Medical Corporation (HMC) Doha Qatar.
  • Abou Kamar MR; Department of Infectious Diseases Communicable Disease Center (CDC) Hamad Medical Corporation (HMC) Doha Qatar.
  • Sharaf Eldean MZ; Department of Laboratory Medicine and Pathology (DLMP) Hamad Medical Corporation (HMC) Doha Qatar.
  • Aldaraiseh BK; Department of Laboratory Medicine and Pathology (DLMP) Hamad Medical Corporation (HMC) Doha Qatar.
  • Nashwan AJ; Critical Care Unit Hazm Mebaireek General Hospital (HMGH) Hamad Medical Corporation (HMC) Doha Qatar.
Clin Case Rep ; 9(1): 148-152, 2021 Jan.
Article in English | MEDLINE | ID: covidwho-919869
Semantic information from SemMedBD (by NLM)
1. tocilizumab CAUSES Cytomegaloviral colitis
Subject
tocilizumab
Predicate
CAUSES
Object
Cytomegaloviral colitis
2. Cytomegaloviral colitis PROCESS_OF Patients
Subject
Cytomegaloviral colitis
Predicate
PROCESS_OF
Object
Patients
3. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
4. Cytomegalovirus Infection Reactivatio PROCESS_OF C0030705
Subject
Cytomegalovirus Infection Reactivatio
Predicate
PROCESS_OF
Object
C0030705
5. Gastrointestinal Hemorrhage PROCESS_OF Patients
Subject
Gastrointestinal Hemorrhage
Predicate
PROCESS_OF
Object
Patients
6. Intestinal Perforation PROCESS_OF Patients
Subject
Intestinal Perforation
Predicate
PROCESS_OF
Object
Patients
7. Therapeutic immunosuppression ADMINISTERED_TO Clinician
Subject
Therapeutic immunosuppression
Predicate
ADMINISTERED_TO
Object
Clinician
8. tocilizumab ADMINISTERED_TO Clinician
Subject
tocilizumab
Predicate
ADMINISTERED_TO
Object
Clinician
9. tocilizumab CAUSES Cytomegaloviral colitis
Subject
tocilizumab
Predicate
CAUSES
Object
Cytomegaloviral colitis
10. Cytomegaloviral colitis PROCESS_OF Patients
Subject
Cytomegaloviral colitis
Predicate
PROCESS_OF
Object
Patients
11. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
12. Cytomegalovirus Infection Reactivation, CTCAE PROCESS_OF Patients
Subject
Cytomegalovirus Infection Reactivation, CTCAE
Predicate
PROCESS_OF
Object
Patients
13. Gastrointestinal Hemorrhage PROCESS_OF Patients
Subject
Gastrointestinal Hemorrhage
Predicate
PROCESS_OF
Object
Patients
14. Intestinal Perforation PROCESS_OF Patients
Subject
Intestinal Perforation
Predicate
PROCESS_OF
Object
Patients
15. Therapeutic immunosuppression ADMINISTERED_TO Clinician
Subject
Therapeutic immunosuppression
Predicate
ADMINISTERED_TO
Object
Clinician
16. tocilizumab ADMINISTERED_TO Clinician
Subject
tocilizumab
Predicate
ADMINISTERED_TO
Object
Clinician
ABSTRACT
The authors urge clinicians to observe for early signs of CMV reactivation in patients presenting with gastrointestinal bleeding and intestinal perforation after receiving tocilizumab or other immunosuppressive therapy as a treatment for COVID 19. Early recognition of CMV infection and treatment will prevent life-threatening bleeding and mortality.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report Language: English Journal: Clin Case Rep Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report Language: English Journal: Clin Case Rep Year: 2021 Document Type: Article