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Safety, pitfalls, and misunderstandings about the use of ozone therapy as a regenerative medicine tool. A narrative review.
Re, L; Noci, J B; Gadelha Serra, M E; Mollica, P; Bonetti, M; Travagli, V.
  • Re L; Facoltà di Medicina e Chirurgia - Università Politecnica delle Marche.
  • Noci JB; Dept. of Embryology and Human Anatomy. Medical School, University of Valencia - Spain.
  • Gadelha Serra ME; Alpha Group Integrative Medicine, São Paulo - Brazil.
  • Mollica P; American College of Integrative Medicine and Dentistry, New Jersey - USA.
  • Bonetti M; Dept. Neuroradiology, Istituto Clinico Città di Brescia, Italy.
  • Travagli V; Dept. of Biotechnology, Chemistry and Pharmacy, Department of National Excellence 2018-2022, University of Siena, Siena, Italy.
J Biol Regul Homeost Agents ; 34(4 Suppl. 1): 1-13. SPECIAL ISSUE: OZONE THERAPY, 2020.
Article in English | MEDLINE | ID: covidwho-919947
Semantic information from SemMedBD (by NLM)
1. Ozone therapy CAUSES Adverse reactions
Subject
Ozone therapy
Predicate
CAUSES
Object
Adverse reactions
2. Ozone therapy TREATS 40 years
Subject
Ozone therapy
Predicate
TREATS
Object
40 years
3. Ozone therapy CAUSES Adverse reactions
Subject
Ozone therapy
Predicate
CAUSES
Object
Adverse reactions
4. Ozone therapy TREATS 40 years
Subject
Ozone therapy
Predicate
TREATS
Object
40 years
ABSTRACT
Despite various opinions and healthy controversy on Ozone Therapy (OT), the practices of this therapy have increased worldwide. Main areas of study with consistent scientific outcomes are the topical treatment of both disk herniation and periodontal disease. On the other hand, there is a net dissociation of the scientific resonance concerning systemic oxygen/ozone treatments. It is our intention to discuss in logical terms the numerous papers that commendably reported adverse reactions attributable to OT, focusing our attention mainly to the techniques of administration and not to the simple contact of ozone with biological material. The case reports on OT treatments safety concerns discussed on international journals, make it possible to state that most safety issues are secondary to infections or traumatic reactions due to malpractice. Commonly, the molecule of ozone itself is not responsible of severe reactions at the therapeutic modalities. The millions of patients treated so far from the thousands of physicians correctly practicing OT world widely in the last 40 years demonstrate the safety of this simple and cost-effective regenerative medicine tool. The promising therapeutic implications also for the current COVID-19 emergency are a further stimulus to the standardization of this therapeutic resource with multiple application specificities.
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Collection: International databases Database: MEDLINE Document Type: Article Main subject: Ozone / Regenerative Medicine Subject: Ozone / Regenerative Medicine Language: English Journal: J Biol Regul Homeost Agents Clinical aspect: Therapy Year: 2020

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Collection: International databases Database: MEDLINE Document Type: Article Main subject: Ozone / Regenerative Medicine Subject: Ozone / Regenerative Medicine Language: English Journal: J Biol Regul Homeost Agents Clinical aspect: Therapy Year: 2020
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