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Major reduction of NKT cells in patients with severe COVID-19 pneumonia.
Zingaropoli, Maria Antonella; Perri, Valentina; Pasculli, Patrizia; Cogliati Dezza, Francesco; Nijhawan, Parni; Savelloni, Giulia; La Torre, Giuseppe; D'Agostino, Claudia; Mengoni, Fabio; Lichtner, Miriam; Ciardi, Maria Rosa; Mastroianni, Claudio Maria.
  • Zingaropoli MA; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy. Electronic address: mariaantonella.zingaropoli@uniroma1.it.
  • Perri V; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
  • Pasculli P; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
  • Cogliati Dezza F; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
  • Nijhawan P; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
  • Savelloni G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
  • La Torre G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
  • D'Agostino C; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
  • Mengoni F; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
  • Lichtner M; Infectious Diseases Unit, SM Goretti Hospital, Polo Pontino, Sapienza University of Rome, Latina, Italy.
  • Ciardi MR; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
  • Mastroianni CM; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
Clin Immunol ; 222: 108630, 2021 01.
Article in English | MEDLINE | ID: covidwho-921852
ABSTRACT

BACKGROUND:

NK cells seem to be mainly involved in COVID-19 pneumonia. Little is known about NKT cells which represent a bridge between innate and adaptive immunity.

METHODS:

We characterized peripheral blood T, NK and NKT cells in 45 patients with COVID-19 pneumonia (COVID-19 subjects) and 19 healthy donors (HDs). According to the severity of the disease, we stratified COVID-19 subjects into severe and non-severe groups.

RESULTS:

Compared to HDs, COVID-19 subjects showed higher percentages of NK CD57+ and CD56dim NK cells and lower percentages of NKT and CD56bright cells. In the severe group we found a significantly lower percentage of NKT cells. In a multiple logistic regression analysis, NKT cell was independently associated with the severity of the disease.

CONCLUSIONS:

The low percentage of NKT cells in peripheral blood of COVID-19 subjects and the independent association with the severity of the disease suggests a potential role of this subset.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Natural Killer T-Cells / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Natural Killer T-Cells / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article