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Clinical features of patients with acute coronary syndrome during the COVID-19 pandemic.
Matsushita, Kensuke; Hess, Sebastien; Marchandot, Benjamin; Sato, Chisato; Truong, Dinh Phi; Kim, Ngoc Thanh; Weiss, Anne; Jesel, Laurence; Ohlmann, Patrick; Morel, Olivier.
  • Matsushita K; Pôle d'Activité Médico-Chirurgicale Cardio-Vasculaire, Nouvel Hôpital Civil, Centre Hospitalier Universitaire, Université de Strasbourg, 1 place de l'Hôpital, 67091, Strasbourg cedex, France.
  • Hess S; UMR1260 INSERM, Nanomédecine Régénérative, Faculté de Pharmacie, Université de Strasbourg, Illkirch, France.
  • Marchandot B; Pôle d'Activité Médico-Chirurgicale Cardio-Vasculaire, Nouvel Hôpital Civil, Centre Hospitalier Universitaire, Université de Strasbourg, 1 place de l'Hôpital, 67091, Strasbourg cedex, France.
  • Sato C; Pôle d'Activité Médico-Chirurgicale Cardio-Vasculaire, Nouvel Hôpital Civil, Centre Hospitalier Universitaire, Université de Strasbourg, 1 place de l'Hôpital, 67091, Strasbourg cedex, France.
  • Truong DP; Pôle d'Activité Médico-Chirurgicale Cardio-Vasculaire, Nouvel Hôpital Civil, Centre Hospitalier Universitaire, Université de Strasbourg, 1 place de l'Hôpital, 67091, Strasbourg cedex, France.
  • Kim NT; UMR1260 INSERM, Nanomédecine Régénérative, Faculté de Pharmacie, Université de Strasbourg, Illkirch, France.
  • Weiss A; Pôle d'Activité Médico-Chirurgicale Cardio-Vasculaire, Nouvel Hôpital Civil, Centre Hospitalier Universitaire, Université de Strasbourg, 1 place de l'Hôpital, 67091, Strasbourg cedex, France.
  • Jesel L; Vietnam National Heart Institute, Bach Mai Hospital, Hanoi, Vietnam.
  • Ohlmann P; Pôle d'Activité Médico-Chirurgicale Cardio-Vasculaire, Nouvel Hôpital Civil, Centre Hospitalier Universitaire, Université de Strasbourg, 1 place de l'Hôpital, 67091, Strasbourg cedex, France.
  • Morel O; Vietnam National Heart Institute, Bach Mai Hospital, Hanoi, Vietnam.
J Thromb Thrombolysis ; 52(1): 95-104, 2021 Jul.
Article in English | MEDLINE | ID: covidwho-926192
Semantic information from SemMedBD (by NLM)
1. Acute Coronary Syndrome COEXISTS_WITH COVID-19
Subject
Acute Coronary Syndrome
Predicate
COEXISTS_WITH
Object
COVID-19
2. Acute Coronary Syndrome PROCESS_OF Patients
Subject
Acute Coronary Syndrome
Predicate
PROCESS_OF
Object
Patients
3. Health care facility LOCATION_OF Analysis
Subject
Health care facility
Predicate
LOCATION_OF
Object
Analysis
4. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
5. D-dimer above reference range PROCESS_OF Patients
Subject
D-dimer above reference range
Predicate
PROCESS_OF
Object
Patients
6. Acute myocardial infarction COEXISTS_WITH COVID-19
Subject
Acute myocardial infarction
Predicate
COEXISTS_WITH
Object
COVID-19
7. ST segment elevation myocardial infarction PROCESS_OF Patients
Subject
ST segment elevation myocardial infarction
Predicate
PROCESS_OF
Object
Patients
8. Emergency medical service METHOD_OF Evaluation
Subject
Emergency medical service
Predicate
METHOD_OF
Object
Evaluation
9. Acute Coronary Syndrome COEXISTS_WITH COVID-19
Subject
Acute Coronary Syndrome
Predicate
COEXISTS_WITH
Object
COVID-19
10. Acute Coronary Syndrome PROCESS_OF Patients
Subject
Acute Coronary Syndrome
Predicate
PROCESS_OF
Object
Patients
11. Health care facility LOCATION_OF Analysis
Subject
Health care facility
Predicate
LOCATION_OF
Object
Analysis
12. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
13. D-dimer above reference range PROCESS_OF Patients
Subject
D-dimer above reference range
Predicate
PROCESS_OF
Object
Patients
14. Acute myocardial infarction COEXISTS_WITH COVID-19
Subject
Acute myocardial infarction
Predicate
COEXISTS_WITH
Object
COVID-19
15. ST segment elevation myocardial infarction PROCESS_OF Patients
Subject
ST segment elevation myocardial infarction
Predicate
PROCESS_OF
Object
Patients
16. Emergency medical service METHOD_OF Evaluation
Subject
Emergency medical service
Predicate
METHOD_OF
Object
Evaluation
ABSTRACT
Although a reduction in hospital admissions of acute coronary syndromes (ACS) patients has been observed globally during the coronavirus disease 2019 (COVID-19) pandemic, clinical features of those patients have not been fully investigated. The aim of the present analysis is to investigate the incidence, clinical presentation, and outcomes of patients with ACS during the COVID-19 pandemic. We performed a retrospective analysis of consecutive patients who were admitted for ACS at our institution between March 1 and April 20, 2020 and compared with the equivalent period in 2019. Admissions for acute myocardial infarction (AMI) reduced by 39.5% in 2020 compared with the equivalent period in 2019. Owing to the emergency medical services (EMS) of our region, all time components of ST-elevated myocardial infarction care were similar during the COVID-19 outbreak as compared with the previous year's dataset. Among the 106 ACS patients in 2020, 7 patients tested positive for COVID-19. Higher incidence of type 2 myocardial infarction (29% vs. 4%, p = 0.0497) and elevated D-dimer levels (5650 µg/l [interquartile range (IQR) 1905-13,625 µg/l] vs. 400 µg/l [IQR 270-1050 µg/l], p = 0.02) were observed in COVID-19 patients. In sum, a significant reduction in admission for AMI was observed during the COVID-19 pandemic. COVID-19 patients were characterized by elevated D-dimer levels on admission, reflecting enhanced COVID-19 related thrombogenicity. The prehospital evaluation by EMS may have played an important role for the timely revascularization for STEMI patients.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Coronary Syndrome / Percutaneous Coronary Intervention / Non-ST Elevated Myocardial Infarction / ST Elevation Myocardial Infarction / COVID-19 / Angina, Unstable Type of study: Diagnostic study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: J Thromb Thrombolysis Journal subject: Vascular Diseases Year: 2021 Document Type: Article Affiliation country: S11239-020-02340-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Coronary Syndrome / Percutaneous Coronary Intervention / Non-ST Elevated Myocardial Infarction / ST Elevation Myocardial Infarction / COVID-19 / Angina, Unstable Type of study: Diagnostic study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: J Thromb Thrombolysis Journal subject: Vascular Diseases Year: 2021 Document Type: Article Affiliation country: S11239-020-02340-z