Determinants of healing among patients with coronavirus disease 2019: the results of the SARS-RAS study of the Italian Society of Hypertension.
J Hypertens
; 39(2): 376-380, 2021 02 01.
Article
in English
| MEDLINE | ID: covidwho-1114884
ABSTRACT
OBJECTIVE:
The burst of COVID-19 epidemics in Italy prompted the Italian Society of Hypertension to start an observational study to explore the characteristics of the hospitalized victims of the disease. The current analysis aimed to investigate the predictors of healing among Italian COVID-19 patients. We also assessed the effect of angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers on the outcome.METHODS:
We designed a cross-sectional, observational, multicenter, nationwide survey in Italy to explore the demographic and clinical characteristics of patients with confirmed COVID-19 infection. We analyzed information from 2446 charts of Italian patients admitted for certified COVID-19 in 27 hospitals. Healing from COVID-19 infection, defined as two consecutive negative swabs, was reported in 544 patients (22.2%), 95% of them were hospitalized.RESULTS:
Age and Charlson Comorbidity Index were significantly lower in healing compared with nonhealing patients (63â±â15 vs. 69â±â15 and 2â±â2 vs. 3â±â2, both Pâ<â0.05). In multivariable regression model, predictors of healing were younger age (OR 0.99; 95% CI 0.98-0.99, Pâ=â0.0001), absence of chronic kidney disease (OR 0.35; 95% CI 0.17-0.70, Pâ=â0.003) or heart failure (OR 0.44; 95% CI, 0.28-0.70, Pâ=â0.001). In the subgroup of patients suffering from hypertension and/or heart failure (nâ=â1498), no differences were observed in the use of ACE inhibitors and angiotensin receptor blockers.CONCLUSION:
Our study demonstrated that younger age and absence of comorbidities play a major role in determining healing in patients with COVID-19. No effects of ACE inhibitors and angiotensin receptor blockers on the outcome was reported.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Angiotensin-Converting Enzyme Inhibitors
/
Renal Insufficiency, Chronic
/
Angiotensin Receptor Antagonists
/
COVID-19
/
Heart Failure
Type of study:
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
/
Young adult
Country/Region as subject:
Europa
Language:
English
Journal:
J Hypertens
Year:
2021
Document Type:
Article
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