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Efficacy and safety of lopinavir/ritonavir in the treatment of COVID-19: A systematic review.
Joseph, Betsy Ann; Dibas, Mahmoud; Evanson, Kirk W; Paranjape, Geeta; Vegivinti, Charan Thej Reddy; Selvan, Pragadeesh Thamarai; Saravu, Kavitha; Gupta, Nitin; Pulakurthi, Yashwitha Sai; Keesari, Praneeth Reddy; Varsha, Sriram; Chittajallu, Spandana; Dmytriw, Adam A; Reierson, Natalie L; Mikoff, Nick; Kamrowski, Shelby; Schmidt, Megan; Davis, Amber R; Pederson, John M; Mishra, Hemant K; Touchette, Jillienne C; Kallmes, Kevin.
  • Joseph BA; Department of Data Research, Nested Knowledge, St. Paul, MN, USA.
  • Dibas M; College of Medicine, Sulaiman Al Rajhi University, Qassim, Saudi Arabia.
  • Evanson KW; Department of Medical Writing, Superior Medical Experts, St. Paul, MN, USA.
  • Paranjape G; Department of Medical Writing, Superior Medical Experts, St. Paul, MN, USA.
  • Vegivinti CTR; Department of General Medicine, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, India.
  • Selvan PT; Department of General Medicine, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, India.
  • Saravu K; Department of Infectious Diseases, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, India.
  • Gupta N; Department of Infectious Diseases, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, India.
  • Pulakurthi YS; Department of Internal Medicine, Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, India.
  • Keesari PR; Department of Internal Medicine, Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, India.
  • Varsha S; Department of Internal Medicine, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, India.
  • Chittajallu S; Department of Internal Medicine, Rangaraya Medical College, Kakinada, India.
  • Dmytriw AA; Neuroradiology & Neurointervention Service, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
  • Reierson NL; Department of Data Research, Nested Knowledge, St. Paul, MN, USA.
  • Mikoff N; Department of Data Research, Nested Knowledge, St. Paul, MN, USA.
  • Kamrowski S; Department of Data Research, Nested Knowledge, St. Paul, MN, USA.
  • Schmidt M; Department of Data Research, Nested Knowledge, St. Paul, MN, USA.
  • Davis AR; Department of Medical Writing, Superior Medical Experts, St. Paul, MN, USA.
  • Pederson JM; Department of Medical Writing, Superior Medical Experts, St. Paul, MN, USA.
  • Mishra HK; Department of Veterinary and Biomedical Sciences, University of Minnesota - Twin Cities, Minneapolis, MN, USA.
  • Touchette JC; Department of Medical Writing, Superior Medical Experts, St. Paul, MN, USA.
  • Kallmes K; Department of Data Research, Nested Knowledge, St. Paul, MN, USA.
Expert Rev Anti Infect Ther ; 19(6): 679-687, 2021 06.
Article in English | MEDLINE | ID: covidwho-927085
Semantic information from SemMedBD (by NLM)
1. lopinavir / ritonavir TREATS Patients
Subject
lopinavir / ritonavir
Predicate
TREATS
Object
Patients
2. lopinavir / ritonavir compared_with Therapeutic procedure
Subject
lopinavir / ritonavir
Predicate
compared_with
Object
Therapeutic procedure
3. Negative PROCESS_OF Patients
Subject
Negative
Predicate
PROCESS_OF
Object
Patients
4. lopinavir / ritonavir TREATS Patients
Subject
lopinavir / ritonavir
Predicate
TREATS
Object
Patients
5. lopinavir / ritonavir compared_with Therapeutic procedure
Subject
lopinavir / ritonavir
Predicate
compared_with
Object
Therapeutic procedure
6. Negative PROCESS_OF Patients
Subject
Negative
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

Objectives:

To systematically review the clinical literature reporting the use of Lopinavir/ritonavir (LPV/r) for the treatment of patients with Cornonavirus disease 19 (COVID-19) to assess the efficacy of LPV/r for the treatment of COVID-19.

Methods:

The authors systematically searched PubMed and MedRxiv databases for studies describing treatment of COVID-19 patients using LPV/r compared to other therapies. Articles were excluded if they were case reports, opinion editorials, preclinical studies, single-armed studies, not written in English, not relevant to the topic, or published before May 2020. The included outcomes were viral clearance as measured by reverse-transcription polymerase chain reaction (RT-PCR) negativity and/or improvement on chest computed tomography (CT), mortality, and adverse events.

Results:

Among 858 total studies, 16 studies met the inclusion criteria and were included in the qualitative review. These studies consisted of 3 randomized control trials, 3 open-label trials, and 10 observational studies. Most of these studies did not report positive clinical outcomes with LPV/r treatment.

Conclusion:

The systematic review revealed insufficient evidence of effectiveness and clinical benefit of LPV/r in the treatment of COVID-19 patients. Specifically, LPV/r does not appear to improve clinical outcome, mortality, time to RT-PCR negativity, or chest CT clearance in patients with COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Antiviral Agents / Ritonavir / Lopinavir / SARS-CoV-2 / COVID-19 Subject: Antiviral Agents / Ritonavir / Lopinavir / SARS-CoV-2 / COVID-19 Type of study: Controlled clinical trial / Observational study / Qualitative research / Systematic review Language: English Journal: Expert Rev Anti Infect Ther Clinical aspect: Therapy Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Antiviral Agents / Ritonavir / Lopinavir / SARS-CoV-2 / COVID-19 Subject: Antiviral Agents / Ritonavir / Lopinavir / SARS-CoV-2 / COVID-19 Type of study: Controlled clinical trial / Observational study / Qualitative research / Systematic review Language: English Journal: Expert Rev Anti Infect Ther Clinical aspect: Therapy Year: 2021
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