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A clinical trial of IL-15 and IL-21 combination therapy for COVID-19 is warranted.
Wilz, Stephen W.
  • Wilz SW; Boston VA Healthcare System, Pathology and Laboratory Medicine, 1400 VFW Parkway, West Roxbury, MA, 02132, United States. Electronic address: stephen.wilz@va.gov.
Cytokine Growth Factor Rev ; 58: 49-50, 2021 04.
Article in English | MEDLINE | ID: covidwho-927134
ABSTRACT
Previous studies of SARS-CoV-2 viral infection suggest that both the humoral and cytotoxic arms of the immune system are weak in patients with severe COVID-19 disease when compared to mild disease. A cytokine storm is also induced in severe disease. IL-15 has been shown to support the cytotoxic arm of the immune response. IL-21 has been shown to support both the cytotoxic and humoral arms of the immune response. In addition, in some settings, Il-21 has been shown to actually decrease IL-6 and TNF-alpha production, reducing the inflammatory proteins involved in the cytokine storm. Furthermore, in other settings, the combination of IL-15 and IL-21 has been shown to be more effective than either interleukin alone in promoting an effective immune response. Therefore, a clinical trial that examines the use of the combination of IL-15 and IL-21 for COVID-19 patients is warranted.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Clinical Trials as Topic / Interleukins / Interleukin-15 / COVID-19 Drug Treatment Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Cytokine Growth Factor Rev Journal subject: Allergy and Immunology / Biochemistry Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Clinical Trials as Topic / Interleukins / Interleukin-15 / COVID-19 Drug Treatment Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Cytokine Growth Factor Rev Journal subject: Allergy and Immunology / Biochemistry Year: 2021 Document Type: Article