ceRNA analysis of SARS-CoV-2.
Arch Virol
; 166(1): 271-274, 2021 Jan.
Article
in English
| MEDLINE | ID: covidwho-1384460
ABSTRACT
Viral RNAs can perturb the miRNA regulatory network, competing with host RNAs as part of their infective process. An in silico competing endogenous RNA (ceRNA) analysis has been carried on SARS-CoV-2. The results suggest that, in humans, the decrease of microRNA activity caused by viral RNAs can lead to a perturbation of vesicle trafficking and the inflammatory response, in particular by enhancing KLF10 activity. The results suggest also that, during the study of the mechanics of viral infections, it could be of general interest to investigate the competition of viral RNA with cellular transcripts for shared microRNAs.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
RNA, Messenger
/
RNA, Viral
/
Gene Regulatory Networks
/
SARS-CoV-2
Limits:
Humans
Language:
English
Journal:
Arch Virol
Year:
2021
Document Type:
Article
Affiliation country:
S00705-020-04856-4
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