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Etoposide as Salvage Therapy for Cytokine Storm Due to Coronavirus Disease 2019.
Patel, Maulin; Dominguez, Eduardo; Sacher, Daniel; Desai, Parag; Chandar, Ashwin; Bromberg, Michael; Caricchio, Roberto; Criner, Gerard J.
  • Patel M; Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA. Electronic address: maulin.patel@tuhs.temple.edu.
  • Dominguez E; Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
  • Sacher D; Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
  • Desai P; Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
  • Chandar A; Department of Hematology and Oncology, Temple University Hospital, Philadelphia, PA.
  • Bromberg M; Department of Hematology and Oncology, Temple University Hospital, Philadelphia, PA.
  • Caricchio R; Department of Rheumatology, Temple University Hospital, Philadelphia, PA.
  • Criner GJ; Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
Chest ; 159(1): e7-e11, 2021 01.
Article in English | MEDLINE | ID: covidwho-1064922
ABSTRACT
Coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality because of a lack of effective therapies. Therapeutic strategies under investigation target the overactive cytokine response with anti-cytokine or immunomodulators therapies. We present a unique case of severe cytokine storm resistant to multiple anti-cytokine therapies, but eventually responsive to etoposide. Thus, etoposide may have a role as salvage therapy in treatment of cytokine storm in COVID-19. To our knowledge, this is the first reported case of use of etoposide in COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Etoposide / Cytokine Release Syndrome / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans Language: English Journal: Chest Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Etoposide / Cytokine Release Syndrome / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans Language: English Journal: Chest Year: 2021 Document Type: Article