Disulfiram Ethanol Reaction with Alcohol-Based Hand Sanitizer: An Exploratory Study.
Alcohol Alcohol
; 56(1): 42-46, 2021 Jan 04.
Article
in English
| MEDLINE | ID: covidwho-929805
ABSTRACT
AIMS:
We conducted a cross-sectional survey to estimate the prevalence and clinical manifestation of disulfiram ethanol reaction (DER) and isopropanol toxicity (IT) in patients with alcohol use disorders, on disulfiram. Alcohol-based hand rub contains either ethanol or isopropanol or both. COVID-19 pandemic has led to wide scale usage of sanitizers. Patients with alcohol use disorders, on disulfiram, might experience disulfiram ethanol like reactions with alcohol-based sanitizers.METHODS:
We telephonically contacted 339 patients, prescribed disulfiram between January 2014 and March 2020. The assessment pertained to the last 3 months (i.e. third week of March to third week of June 2020).RESULT:
The sample consisted of middle-aged men with a mean 16 years of alcohol dependence. Among the 82 (24%) patients adherent to disulfiram, 42 (12.3%) were using alcohol-based hand rubs. Out of these, a total of eight patients (19%; 95% CI 9-33) had features suggestive of DER; four of whom also had features indicative of IT. Five patients (62.5%) had mild and self-limiting symptoms. Severe systemic reactions were experienced by three (37.5%). Severe reactions were observed with exposure to sanitizers in greater amounts, on moist skin or through inhalation.CONCLUSION:
Patients on disulfiram should be advised to use alternate methods of hand hygiene.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Disulfiram
/
Alcohol Deterrents
/
Ethanol
/
Alcoholism
/
Drug-Related Side Effects and Adverse Reactions
/
Hand Sanitizers
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Adult
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Alcohol Alcohol
Year:
2021
Document Type:
Article
Affiliation country:
Alcalc
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