Mechanisms of Hypoxia in COVID-19 Patients: A Pathophysiologic Reflection.
Indian J Crit Care Med
; 24(10): 967-970, 2020 Oct.
Article
in English
| MEDLINE | ID: covidwho-931208
ABSTRACT
Coronavirus disease-2019 (COVID-19) causes severe hypoxemia which fulfills the criteria of acute respiratory distress syndrome (ARDS) but is not accompanied by typical features of the syndrome. The combination of factors including low P/F ratios, high A-a gradient, relatively preserved lung mechanics, and normal pulmonary pressures may imply a process occurring on the vascular side of the alveolar-capillary unit. The scant but rapidly evolving data available on the pathophysiology are seemingly conflicting, indicating the relative dominance of intrapulmonary shunting or dead space in different studies. In this hypothesis paper, we attempt to gather and explain these observations within a unified conceptual framework by invoking the relative contributions of microvascular thrombosis, along with two proposed vascular mechanisms of capillary flow redistribution and flow through intrapulmonary arteriovenous anastomoses (IPAVA). How to cite this article Nitsure M, Sarangi B, Shankar GH, Reddy VS, Walimbe A, Sharma V, et al. Mechanisms of Hypoxia in COVID-19 Patients A Pathophysiologic Reflection. Indian J Crit Care Med 2020;24(10)967-970.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Indian J Crit Care Med
Year:
2020
Document Type:
Article
Affiliation country:
Jp-journals-10071-23547
Similar
MEDLINE
...
LILACS
LIS