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Furin Protease: From SARS CoV-2 to Anthrax, Diabetes, and Hypertension.
Fitzgerald, Kara.
  • Fitzgerald K; Institute for Functional Medicine, Federal Way, WA.
Perm J ; 242020.
Article in English | MEDLINE | ID: covidwho-931342
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ABSTRACT
Furin is a protease that is ubiquitous in mammalian metabolism. One of the innovations that make sudden acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) more infectious than its ancestor viruses is the addition of a furin cleavage site. Conditions associated with elevated furin levels, including diabetes, obesity, and hypertension, overlap greatly with vulnerability to the severe form of coronavirus disease 2019 (COVID-19). We suggest that diet and lifestyle modifications that reduce the associated comorbidities may prevent the development of severe COVID-19 by, in part, lowering circulating furin levels. Likewise, natural and pharmaceutical inhibitors of furin may be candidate prophylactic interventions or, if used early in the COVID-19, may prevent the development of critical symptoms.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severe acute respiratory syndrome-related coronavirus / Furin / Diabetes Mellitus / COVID-19 / Hypertension / Anthrax Limits: Humans Language: English Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severe acute respiratory syndrome-related coronavirus / Furin / Diabetes Mellitus / COVID-19 / Hypertension / Anthrax Limits: Humans Language: English Year: 2020 Document Type: Article