Magnesium and inflammation: Advances and perspectives.
Semin Cell Dev Biol
; 115: 37-44, 2021 07.
Article
in English
| MEDLINE | ID: covidwho-933484
ABSTRACT
Magnesium is an essential element of life, involved in the regulation of metabolism and homeostasis of all the tissues. It also regulates immunological functions, acting on the cells of innate and adaptive immune systems. Magnesium deficiency primes phagocytes, enhances granulocyte oxidative burst, activates endothelial cells and increases the levels of cytokines, thus promoting inflammation. Consequently, a low magnesium status, which is often underdiagnosed, potentiates the reactivity to various immune challenges and is implicated in the pathophysiology of many common chronic diseases. Here we summarize recent advances supporting the link between magnesium deficiency, inflammatory responses and diseases, and offer new hints towards a better understanding of the underlying mechanisms.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Endothelial Cells
/
Inflammation
/
Magnesium
/
Magnesium Deficiency
Limits:
Animals
/
Humans
Language:
English
Journal:
Semin Cell Dev Biol
Journal subject:
Embryology
Year:
2021
Document Type:
Article
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