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Immune suppression in the early stage of COVID-19 disease.
Tian, Wenmin; Zhang, Nan; Jin, Ronghua; Feng, Yingmei; Wang, Siyuan; Gao, Shuaixin; Gao, Ruqin; Wu, Guizhen; Tian, Di; Tan, Wenjie; Chen, Yang; Gao, George Fu; Wong, Catherine C L.
  • Tian W; Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University, 100191, Beijing, China.
  • Zhang N; School of Basic Medical Sciences, Peking University Health Science Center, 100191, Beijing, China.
  • Jin R; Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University, 100191, Beijing, China.
  • Feng Y; School of Basic Medical Sciences, Peking University Health Science Center, 100191, Beijing, China.
  • Wang S; Beijing Youan Hospital, Capital Medical University, 100069, Beijing, China.
  • Gao S; Beijing Youan Hospital, Capital Medical University, 100069, Beijing, China.
  • Gao R; Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University, 100191, Beijing, China.
  • Wu G; Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University, 100191, Beijing, China.
  • Tian D; Qingdao Municipal Center for Disease Control and Prevention, Qingdao, China.
  • Tan W; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), 102206, Beijing, China.
  • Chen Y; Center of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, 100069, Beijing, China.
  • Gao GF; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), 102206, Beijing, China. tanwj@ivdc.chinacdc.cn.
  • Wong CCL; Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University, 100191, Beijing, China. chenyang1816185048@bjmu.edu.cn.
Nat Commun ; 11(1): 5859, 2020 11 17.
Article in English | MEDLINE | ID: covidwho-933687
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
The outbreak of COVID-19 has become a worldwide pandemic. The pathogenesis of this infectious disease and how it differs from other drivers of pneumonia is unclear. Here we analyze urine samples from COVID-19 infection cases, healthy donors and non-COVID-19 pneumonia cases using quantitative proteomics. The molecular changes suggest that immunosuppression and tight junction impairment occur in the early stage of COVID-19 infection. Further subgrouping of COVID-19 patients into moderate and severe types shows that an activated immune response emerges in severely affected patients. We propose a two-stage mechanism of pathogenesis for this unusual viral infection. Our data advance our understanding of the clinical features of COVID-19 infections and provide a resource for future mechanistic and therapeutics studies.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2020 Document Type: Article Affiliation country: S41467-020-19706-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2020 Document Type: Article Affiliation country: S41467-020-19706-9